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    Cd48 CD48 antigen [ Mus musculus (house mouse) ]

    Gene ID: 12506, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cd48provided by MGI
    Official Full Name
    CD48 antigenprovided by MGI
    Primary source
    MGI:MGI:88339
    See related
    Ensembl:ENSMUSG00000015355 AllianceGenome:MGI:88339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BCM1; BLAST; Bcm-1; BLAST1; SLAMF2; Sgp-60; BLAST-1; MEM-102
    Summary
    Acts upstream of or within T cell activation and signal transduction. Located in external side of plasma membrane. Is expressed in several structures, including adipose tissue; bone; hemolymphoid system; liver; and lung. Orthologous to human CD48 (CD48 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 16.9), thymus adult (RPKM 12.5) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cd48 in Genome Data Viewer
    Location:
    1 H3; 1 79.54 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171508989..171532825)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171681245..171705258)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 9 Neighboring gene STARR-positive B cell enhancer ABC_E5848 Neighboring gene SLAM family member 7 Neighboring gene STARR-positive B cell enhancer ABC_E5849 Neighboring gene STARR-positive B cell enhancer ABC_E800 Neighboring gene microRNA 7683 Neighboring gene STARR-positive B cell enhancer ABC_E11696 Neighboring gene STARR-positive B cell enhancer ABC_E2586 Neighboring gene translational machinery associated 7 homolog (S. cerevisiae), pseudogene Neighboring gene adaptor-related protein complex 3, sigma 1 subunit pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CD48-deficient mice have a pronounced defect in CD4(+) T cell activation. González-Cabrero J, et al. Proc Natl Acad Sci U S A, 1999 Feb 2. PMID 9927686, Free PMC Article
    2. CD48 controls T-cell and antigen-presenting cell functions in experimental colitis. Abadía-Molina AC, et al. Gastroenterology, 2006 Feb. PMID 16472597
    3. The murine Cd48 gene: allelic polymorphism in the IgV-like region. Cabrero JG, et al. Eur J Immunogenet, 1998 Dec. PMID 9949948
    4. Identification, by protein sequencing and gene transfection, of sgp-60 as the murine homologue of CD48. Cabrero JG, et al. Proc Natl Acad Sci U S A, 1993 Apr 15. PMID 8475091, Free PMC Article
    5. The SLAM family member CD48 (Slamf2) protects lupus-prone mice from autoimmune nephritis. Koh AE, et al. J Autoimmun, 2011 Aug. PMID 21561736, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Suppression of adaptive NK cell expansion by macrophage-mediated phagocytosis inhibited by 2B4-CD48.
      Title: Suppression of adaptive NK cell expansion by macrophage-mediated phagocytosis inhibited by 2B4-CD48.
    2. Boosting of tau protein aggregation by CD40 and CD48 gene expression in Alzheimer's disease.
      Title: Boosting of tau protein aggregation by CD40 and CD48 gene expression in Alzheimer's disease.
    3. Molecular dynamic simulation explains unbinding and unfolding of CD48-2B4 protein complexes.
      Title: Unbinding and unfolding of adhesion protein complexes through stretching: interplay between shear and tensile mechanical clamps.
    4. These data demonstrate the important role of CD48 in SA/exotoxins-eosinophil activating interactions that can take place during allergic responses and indicate CD48 as a novel therapeutic target for allergy and especially of AD.
      Title: The CD48 receptor mediates Staphylococcus aureus human and murine eosinophil activation.
    5. ORMDL3 promotes eosinophil trafficking and activation via regulation of CD18, CD49d, and CD48.
      Title: ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48.
    6. Ox-LDL significantly promoted the interaction of natural killer cells and dendritic cells via CD48-2B4 contact-dependent mechanisms.
      Title: Ox-LDL can enhance the interaction of mice natural killer cells and dendritic cells via the CD48-2B4 pathway.
    7. B6-specific background genes modulate the effect of CD48 on lupus nephritis in a recessive manner
      Title: The SLAM family member CD48 (Slamf2) protects lupus-prone mice from autoimmune nephritis.
    8. CD48 plays a vital role as an environmental sensor for regulating hematopoietic stem cells and progenitor cell numbers and inhibiting tumor development
      Title: CD48 on hematopoietic progenitors regulates stem cells and suppresses tumor formation.
    9. CD48 on surrounding NK or non-NK cells serves primarily as a ligand to stimulate 2B4 on the adjacent NK cells in mice
      Title: Unidirectional signaling triggered through 2B4 (CD244), not CD48, in murine NK cells.
    10. CD137 and CD28 can promote bcl-2 expression at both mRNA and protein level in T cells.
      Title: [Regulation of Bcl-2 expression in ageing T cells by CD137 and CD28].
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mast cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CD48 antigen
    Names
    BCM1 surface antigen
    HM48-1
    MRC OX-45 surface antigen
    SLAM family member 2
    signaling lymphocytic activation molecule 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360767.1 → NP_001347696.1  CD48 antigen isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC091521
      Consensus CDS
      CCDS87923.1
      UniProtKB/TrEMBL
      F8WHM0, Q8C2T1
      Related
      ENSMUSP00000015499.8, ENSMUST00000015499.14
      Conserved Domains (1) summary
      cd05775
      Location:33 → 124
      Ig_CD2_like_N; N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2 and similar domains

    2. NM_007649.5 → NP_031675.1  CD48 antigen isoform 1 precursor

      See identical proteins and their annotated locations for NP_031675.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC091521, AK084984
      Consensus CDS
      CCDS15501.1
      UniProtKB/Swiss-Prot
      P18181, Q545K2
      UniProtKB/TrEMBL
      Q18PH8, Q6P905
      Related
      ENSMUSP00000064241.6, ENSMUST00000068584.7
      Conserved Domains (2) summary
      smart00410
      Location:29 → 110
      IG_like; Immunoglobulin like
      cl11960
      Location:36 → 124
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171508989..171532825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496637.4 → XP_006496700.1  CD48 antigen isoform X2

    2. XM_006496636.2 → XP_006496699.1  CD48 antigen isoform X1

      UniProtKB/TrEMBL
      Q18PH8, Q6P905
      Conserved Domains (1) summary
      cd05775
      Location:33 → 124
      Ig_CD2_like_N; N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2 and similar domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18181.1 GenPept UniProtKB/Swiss-Prot:P18181

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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