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    Chrm2 cholinergic receptor, muscarinic 2, cardiac [ Mus musculus (house mouse) ]

    Gene ID: 243764, updated on 9-Dec-2024

    Summary

    Official Symbol
    Chrm2provided by MGI
    Official Full Name
    cholinergic receptor, muscarinic 2, cardiacprovided by MGI
    Primary source
    MGI:MGI:88397
    See related
    Ensembl:ENSMUSG00000045613 AllianceGenome:MGI:88397
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    M2; Chrm-2; AChR-M2
    Summary
    Enables G protein-coupled acetylcholine receptor activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within G protein-coupled acetylcholine receptor signaling pathway. Is active in cholinergic synapse. Is expressed in several structures, including alimentary system; central nervous system; heart; sublingual gland primordium; and trigeminal nerve. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; bipolar disorder; heroin dependence; major depressive disorder; and schizophrenia. Orthologous to human CHRM2 (cholinergic receptor muscarinic 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in heart adult (RPKM 12.9), frontal lobe adult (RPKM 3.4) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Chrm2 in Genome Data Viewer
    Location:
    6 B1; 6 15.48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (36364928..36505573)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (36387991..36528638)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15567 Neighboring gene predicted gene, 38790 Neighboring gene predicted gene, 23273 Neighboring gene predicted gene, 57759 Neighboring gene RIKEN cDNA 9330158H04 gene Neighboring gene STARR-seq mESC enhancer starr_15568 Neighboring gene microRNA 490 Neighboring gene STARR-seq mESC enhancer starr_15569 Neighboring gene predicted gene, 53280 Neighboring gene predicted gene, 53281

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled acetylcholine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled acetylcholine receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables G protein-coupled acetylcholine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein-coupled acetylcholine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables arrestin family protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables arrestin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled acetylcholine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in G protein-coupled acetylcholine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G protein-coupled acetylcholine receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in presynaptic modulation of chemical synaptic transmission EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of heart contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of smooth muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in asymmetric synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in asymmetric synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon terminus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cholinergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in cholinergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in symmetric synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in symmetric synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    muscarinic acetylcholine receptor M2
    Names
    AChR M2
    muscarinic acetylcholine receptor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411688.1NP_001398617.1  muscarinic acetylcholine receptor M2

      Status: VALIDATED

      Source sequence(s)
      AC113246, AC159505
      UniProtKB/Swiss-Prot
      E9Q9P0, Q9ERZ4
    2. NM_001411690.1NP_001398619.1  muscarinic acetylcholine receptor M2

      Status: VALIDATED

      Source sequence(s)
      AC113246, AC159505
      UniProtKB/Swiss-Prot
      E9Q9P0, Q9ERZ4
    3. NM_001411691.1NP_001398620.1  muscarinic acetylcholine receptor M2

      Status: VALIDATED

      Source sequence(s)
      AC113246, AC159505
      UniProtKB/Swiss-Prot
      E9Q9P0, Q9ERZ4
    4. NM_001411693.1NP_001398622.1  muscarinic acetylcholine receptor M2

      Status: VALIDATED

      Source sequence(s)
      AC113246, AC159505
      UniProtKB/Swiss-Prot
      E9Q9P0, Q9ERZ4
    5. NM_001411695.1NP_001398624.1  muscarinic acetylcholine receptor M2

      Status: VALIDATED

      Source sequence(s)
      AC113246, AC159505
      UniProtKB/Swiss-Prot
      E9Q9P0, Q9ERZ4
    6. NM_203491.4NP_987076.2  muscarinic acetylcholine receptor M2

      See identical proteins and their annotated locations for NP_987076.2

      Status: VALIDATED

      Source sequence(s)
      AC113246, AC159505
      Consensus CDS
      CCDS20004.1
      UniProtKB/Swiss-Prot
      E9Q9P0, Q9ERZ4
      Related
      ENSMUSP00000130874.2, ENSMUST00000172278.8
      Conserved Domains (1) summary
      cd15297
      Location:24451
      7tmA_mAChR_M2; muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      36364928..36505573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)