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    Cyren cell cycle regulator of NHEJ [ Mus musculus (house mouse) ]

    Gene ID: 78412, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyrenprovided by MGI
    Official Full Name
    cell cycle regulator of NHEJprovided by MGI
    Primary source
    MGI:MGI:1925662
    See related
    Ensembl:ENSMUSG00000046806 AllianceGenome:MGI:1925662
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mri; 3110062M04Rik
    Summary
    Enables damaged DNA binding activity and molecular adaptor activity. Involved in several processes, including DNA metabolic process; positive regulation of double-strand break repair via nonhomologous end joining; and protein localization to site of double-strand break. Part of DNA repair complex. Is active in site of double-strand break. Is expressed in several structures, including adipose tissue; alimentary system; eye; male reproductive gland or organ; and nervous system. Orthologous to human CYREN (cell cycle regulator of NHEJ). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 19.4), subcutaneous fat pad adult (RPKM 12.4) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cyren in Genome Data Viewer
    Location:
    6 B1; 6 15.18 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (34848706..34855024, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (34871771..34878065, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ATP/GTP binding protein-like 3 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 46957 Neighboring gene transmembrane protein 140 Neighboring gene WD repeat domain 91 Neighboring gene STARR-positive B cell enhancer mm9_chr6:34860831-34861132 Neighboring gene stimulated by retinoic acid gene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Generation of a Mouse Model Lacking the Non-Homologous End-Joining Factor Mri/Cyren. Castañeda-Zegarra S, et al. Biomolecules, 2019 Nov 28. PMID 31795137, Free PMC Article
    2. Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI. Castañeda-Zegarra S, et al. Aging (Albany NY), 2020 Dec 7. PMID 33289702, Free PMC Article
    3. Isolation, characterization, and genetic complementation of a cellular mutant resistant to retroviral infection. Agarwal S, et al. Proc Natl Acad Sci U S A, 2006 Oct 24. PMID 17043244, Free PMC Article
    4. MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. Hung PJ, et al. Mol Cell, 2018 Jul 19. PMID 30017584, Free PMC Article
    5. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI.
      Title: Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI.
    2. Characterizes the hamster ortholog and suggests that it may modulate the ability of the proteasome to degrade retroviral cores upon cellular infection.
      Title: Isolation, characterization, and genetic complementation of a cellular mutant resistant to retroviral infection.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular adaptor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in double-strand break repair via nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in immunoglobulin V(D)J recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of double-strand break repair via nonhomologous end joining ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein homooligomerization EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in protein localization to site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA repair complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell cycle regulator of non-homologous end joining
    Names
    modulator of retrovirus infection homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135611.1 → NP_001129083.1  cell cycle regulator of non-homologous end joining isoform 1

      See identical proteins and their annotated locations for NP_001129083.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AK042380, AK083365, BB611813
      Consensus CDS
      CCDS19997.1
      UniProtKB/Swiss-Prot
      Q8BHZ5, Q8K0Y5
      Related
      ENSMUSP00000110659.3, ENSMUST00000115007.9
      Conserved Domains (1) summary
      pfam15325
      Location:55 → 157
      MRI; Modulator of retrovirus infection

    2. NM_001347101.1 → NP_001334030.1  cell cycle regulator of non-homologous end joining isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and in the 3' coding region, compared to variant 1. These differences result in a longer isoform (2), compared to isoform 1.
      Source sequence(s)
      AC153869
      Consensus CDS
      CCDS85030.1
      UniProtKB/Swiss-Prot
      Q8BHZ5
      Related
      ENSMUSP00000110658.2, ENSMUST00000115006.2

    3. NM_199145.2 → NP_954596.1  cell cycle regulator of non-homologous end joining isoform 1

      See identical proteins and their annotated locations for NP_954596.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AK042380, BB611813
      Consensus CDS
      CCDS19997.1
      UniProtKB/Swiss-Prot
      Q8BHZ5, Q8K0Y5
      Related
      ENSMUSP00000053349.5, ENSMUST00000055097.11
      Conserved Domains (1) summary
      pfam15325
      Location:55 → 157
      MRI; Modulator of retrovirus infection

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      34848706..34855024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255676.2 → XP_030111536.1  cell cycle regulator of non-homologous end joining isoform X1

      UniProtKB/Swiss-Prot
      Q8BHZ5, Q8K0Y5
      Conserved Domains (1) summary
      pfam15325
      Location:55 → 157
      MRI; Modulator of retrovirus infection
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHZ5.1 GenPept UniProtKB/Swiss-Prot:Q8BHZ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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