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    Cep162 centrosomal protein 162 [ Mus musculus (house mouse) ]

    Gene ID: 382090, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cep162provided by MGI
    Official Full Name
    centrosomal protein 162provided by MGI
    Primary source
    MGI:MGI:1925343
    See related
    Ensembl:ENSMUSG00000056919 AllianceGenome:MGI:1925343
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1009; 4922501C03Rik
    Summary
    Predicted to be involved in cilium assembly. Predicted to be located in centrosome and cytosol. Predicted to be active in microtubule cytoskeleton and nucleoplasm. Orthologous to human CEP162 (centrosomal protein 162). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.6), CNS E14 (RPKM 2.6) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cep162 in Genome Data Viewer
    Location:
    9 E3.1; 9 46.78 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (87071626..87137589, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (87189573..87255536, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 8282 Neighboring gene melanocortin 2 receptor accessory protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:87150069-87150178 Neighboring gene STARR-seq mESC enhancer starr_24844 Neighboring gene predicted gene, 51416 Neighboring gene predicted gene 9540 Neighboring gene STARR-seq mESC enhancer starr_24845 Neighboring gene T-box18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. QN1/KIAA1009: a new essential protein for chromosome segregation and mitotic spindle assembly. Leon A, et al. Oncogene, 2006 Mar 23. PMID 16302001
    2. Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool. Xie Z, et al. Neuron, 2007 Oct 4. PMID 17920017, Free PMC Article
    3. Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif. Tomsig JL, et al. J Biol Chem, 2003 Mar 21. PMID 12522145
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (3) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1009

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axonemal microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in centriolar satellite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 162 kDa
    Names
    protein QN1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199316.2 → NP_955020.2  centrosomal protein of 162 kDa

      See identical proteins and their annotated locations for NP_955020.2

      Status: VALIDATED

      Source sequence(s)
      AI049385, AK129260, AK135482, BB413728, BC028799, BF465741, BF721651, CB246096, CK639077, CN456181
      Consensus CDS
      CCDS52879.1
      UniProtKB/Swiss-Prot
      B9EKN3, Q6P262, Q6ZQ06
      UniProtKB/TrEMBL
      B9EKT8
      Related
      ENSMUSP00000091319.5, ENSMUST00000093802.6
      Conserved Domains (1) summary
      COG1196
      Location:617 → 1301
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      87071626..87137589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244438.1 → XP_030100298.1  centrosomal protein of 162 kDa isoform X1

      UniProtKB/TrEMBL
      B9EKT8
      Conserved Domains (1) summary
      TIGR02168
      Location:422 → 1165
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_006511263.4 → XP_006511326.1  centrosomal protein of 162 kDa isoform X2

      Conserved Domains (1) summary
      TIGR02168
      Location:31 → 774
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_006511264.1 → XP_006511327.1  centrosomal protein of 162 kDa isoform X3

      Conserved Domains (1) summary
      pfam06785
      Location:610 → 731
      UPF0242; Uncharacterized protein family (UPF0242)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZQ06.2 GenPept UniProtKB/Swiss-Prot:Q6ZQ06

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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