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    Agtr2 angiotensin II receptor, type 2 [ Mus musculus (house mouse) ]

    Gene ID: 11609, updated on 4-Jan-2025

    Summary

    Official Symbol
    Agtr2provided by MGI
    Official Full Name
    angiotensin II receptor, type 2provided by MGI
    Primary source
    MGI:MGI:87966
    See related
    Ensembl:ENSMUSG00000068122 AllianceGenome:MGI:87966
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables angiotensin type II receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; metanephros development; and regulation of systemic arterial blood pressure by renin-angiotensin. Acts upstream of or within brain renin-angiotensin system and inflammatory response. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; brain; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal disease; hypoglycemia; intellectual disability; and vesicoureteral reflux. Orthologous to human AGTR2 (angiotensin II receptor type 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in limb E14.5 (RPKM 70.4) and CNS E14 (RPKM 3.9) See more
    Orthologs
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    Genomic context

    See Agtr2 in Genome Data Viewer
    Location:
    X A2; X 16.71 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (21350863..21355072)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (21484624..21488833)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene 6938 Neighboring gene nucleolar and coiled-body phosphoprotein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_46898 Neighboring gene STARR-seq mESC enhancer starr_46899 Neighboring gene predicted gene, 22592 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 53
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger PubMed 
    involved_in angiotensin-activated signaling pathway  
    involved_in angiotensin-activated signaling pathway PubMed 
    involved_in angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure PubMed 
    acts_upstream_of_or_within angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure PubMed 
    involved_in angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure PubMed 
    acts_upstream_of_or_within brain renin-angiotensin system PubMed 
    involved_in cell growth involved in cardiac muscle cell development  
    involved_in cell growth involved in cardiac muscle cell development  
    involved_in cell surface receptor signaling pathway  
    involved_in cell surface receptor signaling pathway  
    involved_in cellular response to dexamethasone stimulus  
    involved_in cellular response to dexamethasone stimulus  
    involved_in cerebellar cortex development  
    involved_in cerebellar cortex development  
    involved_in dopamine biosynthetic process  
    involved_in dopamine biosynthetic process  
    involved_in exploration behavior PubMed 
    involved_in inflammatory response  
    acts_upstream_of_or_within inflammatory response PubMed 
    involved_in intracellular sodium ion homeostasis  
    involved_in intracellular sodium ion homeostasis  
    involved_in kidney morphogenesis  
    involved_in negative regulation of fibroblast proliferation  
    involved_in negative regulation of fibroblast proliferation  
    involved_in negative regulation of heart rate PubMed 
    involved_in negative regulation of icosanoid secretion  
    involved_in negative regulation of icosanoid secretion  
    NOT acts_upstream_of_or_within negative regulation of neuron apoptotic process PubMed 
    involved_in negative regulation of neurotrophin TRK receptor signaling pathway  
    involved_in negative regulation of neurotrophin TRK receptor signaling pathway  
    involved_in negative regulation of norepinephrine secretion  
    involved_in negative regulation of norepinephrine secretion  
    acts_upstream_of neuron apoptotic process PubMed 
    involved_in nitric oxide-cGMP-mediated signaling PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of branching involved in ureteric bud morphogenesis PubMed 
    involved_in positive regulation of branching involved in ureteric bud morphogenesis  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cytokine production  
    involved_in positive regulation of cytokine production  
    involved_in positive regulation of extrinsic apoptotic signaling pathway  
    involved_in positive regulation of extrinsic apoptotic signaling pathway  
    involved_in positive regulation of metanephric glomerulus development PubMed 
    involved_in regulation of metanephros size PubMed 
    involved_in regulation of protein import into nucleus  
    involved_in regulation of protein import into nucleus  
    involved_in regulation of systemic arterial blood pressure by circulatory renin-angiotensin PubMed 
    involved_in renin-angiotensin regulation of aldosterone production  
    involved_in renin-angiotensin regulation of aldosterone production  
    involved_in vasodilation  
    Items 1 - 25 of 53
    Component Evidence Code Pubs
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    type-2 angiotensin II receptor
    Names
    AT2 receptor
    angiotensin II type-2 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007429.5NP_031455.1  type-2 angiotensin II receptor

      See identical proteins and their annotated locations for NP_031455.1

      Status: VALIDATED

      Source sequence(s)
      AK086334, AK140941
      Consensus CDS
      CCDS40889.1
      UniProtKB/Swiss-Prot
      P35374
      UniProtKB/TrEMBL
      Q3US12
      Related
      ENSMUSP00000086592.3, ENSMUST00000089188.9
      Conserved Domains (1) summary
      pfam00001
      Location:62318
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      21350863..21355072
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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