H2al2a H2A histone family member L2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H2al2aprovided by MGI
Official Full Name: H2A histone family member L2Aprovided by MGI
Primary source: MGI:MGI:1915481
See related: Ensembl:ENSMUSG00000062651 AllianceGenome:MGI:1915481
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H2ab1; H2al2; Tseg1; H2afb1; TSEG-1; H2A.Bbd; H2A.L.2; 1700113O17Rik
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015]
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Genomic context

Location:: 2 A3; 2 12.81 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (18001228..18001769, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (17996417..17996958, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The incorporation of H2A.L.2 initiates and orchestrates a series of successive transitional states that ultimately shift to the fully compacted genome of the mature spermatozoa.
Title: Histone Variant H2A.L.2 Guides Transition Protein-Dependent Protamine Assembly in Male Germ Cells.
These results indicated over-expression of TSEG-1 suppresses the proliferation and induces the apoptosis of GC-1spg cells, which establishes a basis for further study on the function of TSEG-
Title: Over-expression of testis-specific expressed gene 1 attenuates the proliferation and induces apoptosis of GC-1spg cells.
Results indicated that TSEG-1 was cloned from X chromosome, with full-length sequence of 510 bp. The ORF is 336 bp that en-codes a deduced amino acid sequence of 111 residues. It was distinctively expressed in testis, but not in other tissues . : [TSEG-1]
Title: [Cloning and sequence analysis of TSEG-1, a novel gene specifically expressed in mouse testis].
The unusual properties of the H2AL2 nucleosomes suggest a specific role of H2AL2 during mouse spermiogenesis.
Title: The incorporation of the novel histone variant H2AL2 confers unusual structural and functional properties of the nucleosome.
H2AL1 and H2AL2, specifically mark the pericentric regions in condensing spermatids and participate in the formation of new nucleoprotein structures
Title: Pericentric heterochromatin reprogramming by new histone variants during mouse spermiogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables histone binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromosome organization	IDA Inferred from Direct Assay more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nucleosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in sperm DNA condensation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of nucleosome	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleosome	IDA Inferred from Direct Assay more info	PubMed
part_of nucleosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in pericentric heterochromatin	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histone H2A-Bbd type 1

Names: H2A Barr body-deficient; H2A histone family, member B1; histone H2A-like 2; histone H2Alike 2; histone variant H2al2; testis-specific expressed gene 1 protein; testis-specific expressed protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026627.2 → NP_080903.1 histone H2A-Bbd type 1

See identical proteins and their annotated locations for NP_080903.1

Status: REVIEWED

Source sequence(s)

AL928589

Consensus CDS

CCDS38050.1

UniProtKB/Swiss-Prot

Q9CQ70, Q9D9Q5

Related

ENSMUSP00000100618.3, ENSMUST00000105001.4

Conserved Domains (1) summary

cl23907
Location:13 → 99

H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...