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    St7l suppression of tumorigenicity 7-like [ Mus musculus (house mouse) ]

    Gene ID: 229681, updated on 9-Dec-2024

    Summary

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    Official Symbol
    St7lprovided by MGI
    Official Full Name
    suppression of tumorigenicity 7-likeprovided by MGI
    Primary source
    MGI:MGI:2386964
    See related
    Ensembl:ENSMUSG00000045576 AllianceGenome:MGI:2386964
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    St7r
    Summary
    Involved in negative regulation of cell growth. Predicted to be located in membrane. Is expressed in several structures, including genitourinary system; inner ear; liver; lung; and spleen. Orthologous to human ST7L (suppression of tumorigenicity 7 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 3.0), limb E14.5 (RPKM 2.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See St7l in Genome Data Viewer
    Location:
    3 F2.2; 3 45.88 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (104771822..104837384)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (104864506..104949328)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene Mov10 RISC complex RNA helicase Neighboring gene STARR-seq mESC enhancer starr_08622 Neighboring gene capping actin protein of muscle Z-line subunit alpha 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:104667925-104668034 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08625 Neighboring gene wingless-type MMTV integration site family, member 2B Neighboring gene predicted gene, 46819

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ST7-mediated suppression of tumorigenicity of prostate cancer cells is characterized by remodeling of the extracellular matrix. Hooi CF, et al. Oncogene, 2006 Jun 29. PMID 16474848
    2. Molecular cloning and characterization of mouse St7r (St7-like, St7l). Saitoh T, et al. Int J Mol Med, 2002 Jul. PMID 12060862
    3. Analysis of genes from inner ear developmental-stage cDNA subtraction reveals molecular regionalization of the otic capsule. Ficker M, et al. Dev Biol, 2004 Apr 1. PMID 15031101
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the first report on molecular cloning and initial characterization of mouse St7r
      Title: Molecular cloning and characterization of mouse St7r (St7-like, St7l).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130399

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    suppressor of tumorigenicity 7 protein-like
    Names
    ST7-related protein
    tumor suppressor ST7 like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253702.1 → NP_001240631.1  suppressor of tumorigenicity 7 protein-like isoform 2

      See identical proteins and their annotated locations for NP_001240631.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC166156, AI834981, AK030273, BC058781
      Consensus CDS
      CCDS57250.1
      UniProtKB/Swiss-Prot
      Q8K4P7
      UniProtKB/TrEMBL
      Q8CDC5
      Related
      ENSMUSP00000102380.2, ENSMUST00000106769.8
      Conserved Domains (1) summary
      cd11557
      Location:75 → 510
      ST7; Suppression of tumorigenicity 7

    2. NM_001253703.1 → NP_001240632.1  suppressor of tumorigenicity 7 protein-like isoform 3

      See identical proteins and their annotated locations for NP_001240632.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame internal segment compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC166156, AI834981, AK030273, AK144075
      Consensus CDS
      CCDS79994.1
      UniProtKB/Swiss-Prot
      Q8K4P7
      UniProtKB/TrEMBL
      Q8CDC5
      Related
      ENSMUSP00000143759.2, ENSMUST00000200132.5
      Conserved Domains (1) summary
      cd11557
      Location:75 → 464
      ST7; Suppression of tumorigenicity 7

    3. NM_153091.3 → NP_694731.1  suppressor of tumorigenicity 7 protein-like isoform 1

      See identical proteins and their annotated locations for NP_694731.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC166156, AI834981, AK030273, BC058781
      Consensus CDS
      CCDS17705.1
      UniProtKB/Swiss-Prot
      Q3T9Y2, Q3UNR1, Q8K4P7
      Related
      ENSMUSP00000058455.7, ENSMUST00000059271.13
      Conserved Domains (1) summary
      cd11557
      Location:75 → 542
      ST7; Suppression of tumorigenicity 7

    RNA

    1. NR_045578.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of an exon compared to variant 1, that causes a frameshift. This transcript is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC166156, AI834981, AK030273, AK148099, BC058781

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      104771822..104837384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252589.2 → XP_030108449.1  suppressor of tumorigenicity 7 protein-like isoform X1

      Conserved Domains (1) summary
      cd11557
      Location:1 → 330
      ST7; Suppression of tumorigenicity 7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K4P7.1 GenPept UniProtKB/Swiss-Prot:Q8K4P7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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