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    Mospd3 motile sperm domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 68929, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mospd3provided by MGI
    Official Full Name
    motile sperm domain containing 3provided by MGI
    Primary source
    MGI:MGI:1916179
    See related
    Ensembl:ENSMUSG00000037221 AllianceGenome:MGI:1916179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    R124; Gtig2; 1190005J19Rik; 5133401H10Rik
    Summary
    Acts upstream of or within heart development. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human MOSPD3 (motile sperm domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 55.5), thymus adult (RPKM 49.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mospd3 in Genome Data Viewer
    Location:
    5 G2; 5 76.59 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137594907..137599342, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137596645..137601079, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene actin-like 6B Neighboring gene transferrin receptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E2180 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:138038199-138038386 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:138041904-138042125 Neighboring gene STARR-positive B cell enhancer ABC_E281 Neighboring gene predicted gene 7285 Neighboring gene procollagen C-endopeptidase enhancer protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Methylation of lncSHGL promotes adipocyte differentiation by regulating miR-149/Mospd3 axis. Huang X, et al. Cell Cycle, 2023 Nov. PMID 38057958,
    2. Gene trap integrations expressed in the developing heart: insertion site affects splicing of the PT1-ATG vector. McClive P, et al. Dev Dyn, 1998 Jun. PMID 9626501
    3. Hypersensitivity to pentylenetetrazol-induced convulsion in mice lacking the PLC-related inactive protein-1. Yamaguchi T, et al. Brain Res, 2004 Oct 29. PMID 15464766
    4. An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro. Forrester LM, et al. Proc Natl Acad Sci U S A, 1996 Feb 20. PMID 8643689, Free PMC Article
    5. A novel transmembrane MSP-containing protein that plays a role in right ventricle development. Pall GS, et al. Genomics, 2004 Dec. PMID 15533722

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Methylation of lncSHGL promotes adipocyte differentiation by regulating miR-149/Mospd3 axis.
      Title: Methylation of lncSHGL promotes adipocyte differentiation by regulating miR-149/Mospd3 axis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    motile sperm domain-containing protein 3
    Names
    gene trap integration gene 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001254762.1 → NP_001241691.1  motile sperm domain-containing protein 3

      See identical proteins and their annotated locations for NP_001241691.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC148018, AW050147, BQ445267, CK617131
      Consensus CDS
      CCDS19771.1
      UniProtKB/Swiss-Prot
      Q8BGG6
      UniProtKB/TrEMBL
      Q05DT5
      Related
      ENSMUSP00000106636.2, ENSMUST00000111007.8
      Conserved Domains (1) summary
      pfam00635
      Location:41 → 133
      Motile_Sperm; MSP (Major sperm protein) domain

    2. NM_030037.2 → NP_084313.1  motile sperm domain-containing protein 3

      See identical proteins and their annotated locations for NP_084313.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC148018, AI845922, AK004495, AK019892, BE861793, DV656015
      Consensus CDS
      CCDS19771.1
      UniProtKB/Swiss-Prot
      Q8BGG6
      UniProtKB/TrEMBL
      Q05DT5
      Related
      ENSMUSP00000040828.8, ENSMUST00000037620.14
      Conserved Domains (1) summary
      pfam00635
      Location:41 → 133
      Motile_Sperm; MSP (Major sperm protein) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      137594907..137599342 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504613.5 → XP_006504676.1  motile sperm domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006504676.1

      Conserved Domains (1) summary
      pfam00635
      Location:41 → 133
      Motile_Sperm; MSP (Major sperm protein) domain

    2. XM_006504614.5 → XP_006504677.1  motile sperm domain-containing protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006504677.1

      UniProtKB/Swiss-Prot
      Q8BGG6
      UniProtKB/TrEMBL
      Q05DT5
      Conserved Domains (1) summary
      pfam00635
      Location:41 → 133
      Motile_Sperm; MSP (Major sperm protein) domain

    3. XM_006504612.2 → XP_006504675.1  motile sperm domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006504675.1

      Conserved Domains (1) summary
      pfam00635
      Location:41 → 133
      Motile_Sperm; MSP (Major sperm protein) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGG6.1 GenPept UniProtKB/Swiss-Prot:Q8BGG6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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