Obp1a odorant binding protein IA [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Obp1aprovided by MGI
Official Full Name: odorant binding protein IAprovided by MGI
Primary source: MGI:MGI:1277949
See related: Ensembl:ENSMUSG00000067684 AllianceGenome:MGI:1277949
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OBP5; OBP-1a
Summary: Enables odorant binding activity. Predicted to be involved in sensory perception of smell. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: X B; X 38.33 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (77129111..77134980, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (78085505..78091374, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel lacrimal gland autoantigen OBP1a is expressed in the thymus in an Aire-dependent fashion, suggesting that defective thymic expression of OBP1a may play a role in the spontaneous dacryoadenitis that develops in the Aire-deficient mouse model.
Title: An autoimmune response to odorant binding protein 1a is associated with dry eye in the Aire-deficient mouse.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493087

NoName (e-PCR)
- UniSTS:495475

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables odorant binding	IBA Inferred from Biological aspect of Ancestor more info
enables odorant binding	IDA Inferred from Direct Assay more info	PubMed
enables small molecule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in sensory perception of smell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: odorant-binding protein 1a

Names: odorant binding protein 5; odorant-binding protein Ia

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008754.2 → NP_032780.2 odorant-binding protein 1a precursor

Status: PROVISIONAL

Source sequence(s)

AK017455

Consensus CDS

CCDS30251.1

UniProtKB/Swiss-Prot

P97336, Q9D3H2

UniProtKB/TrEMBL

A0A0D3M042

Related

ENSMUSP00000085531.2, ENSMUST00000088201.2

Conserved Domains (1) summary

pfam00061
Location:20 → 159

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family