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    NOL4L nucleolar protein 4 like [ Homo sapiens (human) ]

    Gene ID: 140688, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NOL4Lprovided by HGNC
    Official Full Name
    nucleolar protein 4 likeprovided by HGNC
    Primary source
    HGNC:HGNC:16106
    See related
    Ensembl:ENSG00000197183 MIM:618893; AllianceGenome:HGNC:16106
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C20orf112; C20orf113
    Summary
    Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 8.2), small intestine (RPKM 6.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NOL4L in Genome Data Viewer
    Location:
    20q11.21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (32443059..32585333, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (34167910..34310868, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (31030862..31173135, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30865306-30865816 Neighboring gene kinesin family member 3B Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:30914131-30915330 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12783 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17716 Neighboring gene ASXL transcriptional regulator 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31033225-31033886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31035799-31036300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31044389-31045304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31045305-31046220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31046221-31047136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31062343-31063114 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31064659-31065430 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12789 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12790 Neighboring gene uncharacterized LOC124904886 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31084748-31085264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31093704-31094386 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31094387-31095068 Neighboring gene uncharacterized LOC101929698 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:31098781-31099176 Neighboring gene VISTA enhancer hs2225 Neighboring gene Sharpr-MPRA regulatory region 5058 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12791 Neighboring gene uncharacterized LOC105372592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31124544-31125515 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31126487-31127458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31128887-31129392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31129393-31129898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31149672-31150323 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31151241-31151782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31158183-31158907 Neighboring gene Sharpr-MPRA regulatory region 4335 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31164325-31165278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31168247-31168946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12799 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12797 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12795 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12800 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17718 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31184984-31185484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31185485-31185985 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31186003-31186504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31189553-31190054 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12803 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31193059-31193558 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:31193901-31194067 Neighboring gene NOL4L divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31198315-31198930 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31198931-31199544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31206902-31207402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31211056-31211606 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12804 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:31226322-31226509 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31226763-31227262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31235460-31235960 Neighboring gene chromosome 20 open reading frame 203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31235961-31236461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17719 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12805 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31252264-31252832 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31252833-31253400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31254622-31255122 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31259991-31260490

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Dominant-negative mechanism of leukemogenic PAX5 fusions. Kawamata N, et al. Oncogene, 2012 Feb 23. PMID 21765475, Free PMC Article
    2. NOL4L, a novel nuclear protein, promotes cell proliferation and metastasis by enhancing the PI3K/AKT pathway in ovarian cancer. Lin F, et al. Biochem Biophys Res Commun, 2021 Jun 25. PMID 33940382
    3. LncRNA double homeobox A pseudogene 8 (DUXAP8) facilitates the progression of neuroblastoma and activates Wnt/β-catenin pathway via microRNA-29/nucleolar protein 4 like (NOL4L) axis. Nie L, et al. Brain Res, 2020 Nov 1. PMID 32522628
    4. CBFA2T2 and C20orf112: two novel fusion partners of RUNX1 in acute myeloid leukemia. Guastadisegni MC, et al. Leukemia, 2010 Aug. PMID 20520637
    5. Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex. Spruijt CG, et al. FEBS J, 2021 May. PMID 33283408, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA double homeobox A pseudogene 8 (DUXAP8) facilitates the progression of neuroblastoma and activates Wnt/beta-catenin pathway via microRNA-29/nucleolar protein 4 like (NOL4L) axis.
      Title: LncRNA double homeobox A pseudogene 8 (DUXAP8) facilitates the progression of neuroblastoma and activates Wnt/β-catenin pathway via microRNA-29/nucleolar protein 4 like (NOL4L) axis.
    2. NOL4L, a novel nuclear protein, promotes cell proliferation and metastasis by enhancing the PI3K/AKT pathway in ovarian cancer.
      Title: NOL4L, a novel nuclear protein, promotes cell proliferation and metastasis by enhancing the PI3K/AKT pathway in ovarian cancer.
    3. the leukemogenic PAX5-C20S fusion protein is a tetramer, which interacts extraordinarily stably with chromatin as determined by Fluorescence Recovery After Photobleaching in living cells
      Title: Dominant-negative mechanism of leukemogenic PAX5 fusions.
    4. report characterization of two chimeric transcripts identified in AML translocation cases involving CBFA2T2 and C20orf112
      Title: CBFA2T2 and C20orf112: two novel fusion partners of RUNX1 in acute myeloid leukemia.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • dJ1184F4.2, dJ1184F4.4, DKFZp566G1424

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar protein 4-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256798.2 → NP_001243727.1  nucleolar protein 4-like isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1).
      Source sequence(s)
      AK056286, AL122043, AL133343, AL834520, BC023657, BC065370, BQ067609, BX281715
      Consensus CDS
      CCDS74718.1
      UniProtKB/TrEMBL
      A0A087X0N3
      Related
      ENSP00000483523.1, ENST00000621426.7
      Conserved Domains (1) summary
      pfam17921
      Location:131 → 185
      Integrase_H2C2; Integrase zinc binding domain

    2. NM_001351680.2 → NP_001338609.1  nucleolar protein 4-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL034550

    3. NM_080616.6 → NP_542183.2  nucleolar protein 4-like isoform 2

      See identical proteins and their annotated locations for NP_542183.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1. This results in translation initiation from an in-frame, downstream AUG, and an isofom (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK056286, AL122043, AL834520, BC038088, BC065370, BX281715
      Consensus CDS
      CCDS13202.1
      UniProtKB/Swiss-Prot
      Q5JYB7, Q6P0Y4, Q96MY1, Q9BR34, Q9NQF6
      Related
      ENSP00000352704.5, ENST00000359676.9

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      32443059..32585333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      34167910..34310868 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96MY1.2 GenPept UniProtKB/Swiss-Prot:Q96MY1

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