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    FCGR3B Fc gamma receptor IIIb [ Homo sapiens (human) ]

    Gene ID: 2215, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FCGR3Bprovided by HGNC
    Official Full Name
    Fc gamma receptor IIIbprovided by HGNC
    Primary source
    HGNC:HGNC:3620
    See related
    Ensembl:ENSG00000162747 MIM:610665; AllianceGenome:HGNC:3620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD16; FCG3; CD16A; CD16b; FCGR3; CD16-I; FCGR3A; FCR-10; FCRIII; FCRIIIb
    Summary
    The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]
    Expression
    Biased expression in spleen (RPKM 53.3), appendix (RPKM 50.9) and 7 other tissues See more
    Orthologs
    all
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    Genomic context

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    See FCGR3B in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161623196..161631963, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160967541..160976307, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161592986..161601753, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:161581576-161582270 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:161582271-161582964 Neighboring gene tRNA-Leu (anticodon CAA) 6-1 Neighboring gene ribosomal protein S23 pseudogene 9 Neighboring gene Sharpr-MPRA regulatory region 4269 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:161608151-161608340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1483 Neighboring gene Fc gamma receptor IIb Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:161640790-161641368 Neighboring gene ribosomal protein L31 pseudogene 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Low copy number of the Fc-γ receptor 3B gene FCGR3B is a risk factor for primary Sjogren's syndrome. Nossent JC, et al. J Rheumatol, 2012 Nov. PMID 22942264
    2. FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans. Molokhia M, et al. Rheumatology (Oxford), 2011 Jul. PMID 21296850, Free PMC Article
    3. Increased frequency of FcgammaRIIIb-NA1 allele in periodontitis-resistant subjects in an elderly Japanese population. Sugita N, et al. J Dent Res, 2001 Mar. PMID 11379895
    4. FCGR3B*03 allele inheritance pattern in Brazilian families and some new variants of gene FCGR3B. Terzian CC, et al. Transfusion, 2012 Mar. PMID 21895673
    5. Human CD16+ and CD16- monocyte subsets display unique effector properties in inflammatory conditions in vivo. Aguilar-Ruiz SR, et al. J Leukoc Biol, 2011 Dec. PMID 21937707

    See all (213) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association of Fc Gamma Receptor 3B Gene Copy Number Variation with Rheumatoid Arthritis Susceptibility.
      Title: Association of Fc Gamma Receptor 3B Gene Copy Number Variation with Rheumatoid Arthritis Susceptibility.
    2. Single-cell analyses identify dysfunctional CD16(+) CD8 T cells in smokers.
      Title: Single-cell analyses identify dysfunctional CD16(+) CD8 T cells in smokers.
    3. Significant differences in FcgammaRIIa, FcgammaRIIIa and FcgammaRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children.
      Title: Significant differences in FcγRIIa, FcγRIIIa and FcγRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children.
    4. Low-affinity immunoglobulin gamma Fc region receptor III-B (FcgammaRIIIB, CD16B) deficiency in patients with blood and immune system disorders.
      Title: Low-affinity immunoglobulin gamma Fc region receptor III-B (FcγRIIIB, CD16B) deficiency in patients with blood and immune system disorders.
    5. The Antibody Receptor Fc Gamma Receptor IIIb Induces Calcium Entry via Transient Receptor Potential Melastatin 2 in Human Neutrophils.
      Title: The Antibody Receptor Fc Gamma Receptor IIIb Induces Calcium Entry via Transient Receptor Potential Melastatin 2 in Human Neutrophils.
    6. Lower HDL-C levels are associated with higher expressions of CD16 on monocyte subsets in coronary atherosclerosis.
      Title: Lower HDL-C levels are associated with higher expressions of CD16 on monocyte subsets in coronary atherosclerosis.
    7. FCGR Genetic Variation in Two Populations From Ecuador Highlands-Extensive Copy-Number Variation, Distinctive Distribution of Functional Polymorphisms, and a Novel, Locally Common, Chimeric FCGR3B/A (CD16B/A) Gene.
      Title: FCGR Genetic Variation in Two Populations From Ecuador Highlands-Extensive Copy-Number Variation, Distinctive Distribution of Functional Polymorphisms, and a Novel, Locally Common, Chimeric FCGR3B/A (CD16B/A) Gene.
    8. Susceptibility to Plasmodium falciparum Malaria: Influence of Combined Polymorphisms of IgG3 Gm Allotypes and Fc Gamma Receptors IIA, IIIA, and IIIB.
      Title: Susceptibility to Plasmodium falciparum Malaria: Influence of Combined Polymorphisms of IgG3 Gm Allotypes and Fc Gamma Receptors IIA, IIIA, and IIIB.
    9. Aberrant FcgammaRIIb and FcgammaRIII expression on monocytes from patients with Behcet's disease.
      Title: Aberrant FcγRIIb and FcγRIII expression on monocytes from patients with Behçet's disease.
    10. FCGR3B polymorphism predicts relapse risk in eosinophilic granulomatosis with polyangiitis.
      Title: FCGR3B polymorphism predicts relapse risk in eosinophilic granulomatosis with polyangiitis.
    Submit: New GeneRIF Correction See all GeneRIFs (132)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120 PubMed
    Tat tat HIV-1 Tat upregulates the expression of CCR2, CD16, and TLR4 in monocyte-derived macrophages PubMed
    tat HIV-1 Tat inhibits the rise in intracellular free calcium concentration in Natural Killer (NK) cells upon cross-linking of the adhesion molecule CD11a and the activation molecule CD16, indicating Tat is involved in the impairment of NK cell function PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GPI anchor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables IgG binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables IgG receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Fc-gamma receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in antibody-dependent cellular cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    low affinity immunoglobulin gamma Fc region receptor III-B
    Names
    Fc fragment of IgG receptor IIIb
    Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
    Fc gamma receptor III-B
    Fc-gamma receptor IIIb (CD 16)
    FcgammaRIIIb
    fc-gamma RIII-beta
    fc-gamma RIIIb
    igG Fc receptor III-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032926.2 RefSeqGene

      Range
      5788..13768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1238

    mRNA and Protein(s)

    1. NM_000570.5 → NP_000561.3  low affinity immunoglobulin gamma Fc region receptor III-B isoform 2 precursor

      See identical proteins and their annotated locations for NP_000561.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (2).
      Source sequence(s)
      AL451067
      Consensus CDS
      CCDS41433.1
      UniProtKB/Swiss-Prot
      O75015
      UniProtKB/TrEMBL
      A0A3B3ISU3, Q9UPY7
      Related
      ENSP00000356941.2, ENST00000367964.6
      Conserved Domains (2) summary
      cd05752
      Location:26 → 104
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:108 → 190
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

    2. NM_001244753.2 → NP_001231682.2  low affinity immunoglobulin gamma Fc region receptor III-B isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (2). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AJ581669, AL451067, M24854, X16863
      Consensus CDS
      CCDS41433.1
      UniProtKB/Swiss-Prot
      O75015
      UniProtKB/TrEMBL
      A0A3B3ISU3, Q9UPY7
      Related
      ENSP00000497461.1, ENST00000650385.1
      Conserved Domains (2) summary
      cd05752
      Location:26 → 104
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:108 → 190
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

    3. NM_001271035.2 → NP_001257964.2  low affinity immunoglobulin gamma Fc region receptor III-B isoform 6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site at the 5' end of an exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is one aa shorter compared to isoform 2.
      Source sequence(s)
      AJ581669, AK316565, AL451067, DA673839
      Consensus CDS
      CCDS91090.1
      UniProtKB/TrEMBL
      H0Y4U3, Q9UPY7
      Related
      ENSP00000394204.3, ENST00000421702.4
      Conserved Domains (2) summary
      cd05752
      Location:25 → 103
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:107 → 189
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

    4. NM_001271036.2 → NP_001257965.1  low affinity immunoglobulin gamma Fc region receptor III-B isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL451067
      UniProtKB/TrEMBL
      Q9UPY7
      Conserved Domains (2) summary
      cd05752
      Location:9 → 87
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
      cd05753
      Location:91 → 173
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

    5. NM_001271037.2 → NP_001257966.1  low affinity immunoglobulin gamma Fc region receptor III-B isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AL451067
      UniProtKB/Swiss-Prot
      O75015
      UniProtKB/TrEMBL
      A0A087WU90
      Conserved Domains (1) summary
      cd05752
      Location:9 → 87
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      161623196..161631963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      160967541..160976307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75015.3 GenPept UniProtKB/Swiss-Prot:O75015

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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