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    FGL1 fibrinogen like 1 [ Homo sapiens (human) ]

    Gene ID: 2267, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FGL1provided by HGNC
    Official Full Name
    fibrinogen like 1provided by HGNC
    Primary source
    HGNC:HGNC:3695
    See related
    Ensembl:ENSG00000104760 MIM:605776; AllianceGenome:HGNC:3695
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HPS; HFREP1; HP-041; LFIRE1; LFIRE-1
    Summary
    Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward liver (RPKM 275.4) See more
    Orthologs
    mouse all
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    Genomic context

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    See FGL1 in Genome Data Viewer
    Location:
    8p22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (17864389..17895538, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (18131895..18183454, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (17721898..17753047, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microtubule associated scaffold protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18965 Neighboring gene MTUS1 divergent transcript Neighboring gene uncharacterized LOC124901893 Neighboring gene endogenous retrovirus group K member 25 Env polyprotein-like Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:17769002-17769792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:17769793-17770581 Neighboring gene Sharpr-MPRA regulatory region 2266 Neighboring gene uncharacterized LOC124901867 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27048 Neighboring gene Sharpr-MPRA regulatory region 9839 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27049 Neighboring gene pericentriolar material 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer. Li JJ, et al. Nat Commun, 2023 Oct 23. PMID 37872170, Free PMC Article
    2. Hepassocin regulates cell proliferation of the human hepatic cells L02 and hepatocarcinoma cells through different mechanisms. Cao MM, et al. J Cell Biochem, 2011 Oct. PMID 21618590
    3. Hepatocyte-derived fibrinogen-related protein-1 is associated with the fibrin matrix of a plasma clot. Rijken DC, et al. Biochem Biophys Res Commun, 2006 Nov 10. PMID 16996032
    4. LFIRE-1/HFREP-1, a liver-specific gene, is frequently downregulated and has growth suppressor activity in hepatocellular carcinoma. Yan J, et al. Oncogene, 2004 Mar 11. PMID 14981537
    5. Functional expression of hepassocin in Escherichia coli using SUMO fusion partner and molecular chaperones. Wang Q, et al. Protein Expr Purif, 2013 Dec. PMID 24084006

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FGL1: a novel biomarker and target for non-small cell lung cancer, promoting tumor progression and metastasis through KDM4A/STAT3 transcription mechanism.
      Title: FGL1: a novel biomarker and target for non-small cell lung cancer, promoting tumor progression and metastasis through KDM4A/STAT3 transcription mechanism.
    2. The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer.
      Title: The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer.
    3. Clinical Significance and Prognostic Value of the Expression of LAG-3 and FGL1 in Esophageal Squamous Cell Carcinoma.
      Title: Clinical Significance and Prognostic Value of the Expression of LAG-3 and FGL1 in Esophageal Squamous Cell Carcinoma.
    4. Fibrinogen-like protein 1 promotes liver-resident memory T-cell exhaustion in hepatocellular carcinoma.
      Title: Fibrinogen-like protein 1 promotes liver-resident memory T-cell exhaustion in hepatocellular carcinoma.
    5. Dual immunological and proliferative regulation of immune checkpoint FGL1 in lung adenocarcinoma: The pivotal role of the YY1-FGL1-MYH9 axis.
      Title: Dual immunological and proliferative regulation of immune checkpoint FGL1 in lung adenocarcinoma: The pivotal role of the YY1-FGL1-MYH9 axis.
    6. Serum fibrinogen-like protein 1 as a novel biomarker in polycystic ovary syndrome: a case-control study.
      Title: Serum fibrinogen-like protein 1 as a novel biomarker in polycystic ovary syndrome: a case-control study.
    7. Engineered Small Extracellular Vesicles as a FGL1/PD-L1 Dual-Targeting Delivery System for Alleviating Immune Rejection.
      Title: Engineered Small Extracellular Vesicles as a FGL1/PD-L1 Dual-Targeting Delivery System for Alleviating Immune Rejection.
    8. Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target.
      Title: Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target.
    9. Proteomics identifies a novel role of fibrinogen-like protein 1 in Crohn's disease.
      Title: Proteomics identifies a novel role of fibrinogen-like protein 1 in Crohn's disease.
    10. Eicosapentaenoic Acid Inhibits KRAS Mutant Pancreatic Cancer Cell Growth by Suppressing Hepassocin Expression and STAT3 Phosphorylation.
      Title: Eicosapentaenoic Acid Inhibits KRAS Mutant Pancreatic Cancer Cell Growth by Suppressing Hepassocin Expression and STAT3 Phosphorylation.
    Submit: New GeneRIF Correction See all GeneRIFs (34)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC12455

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hepatocyte proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of T cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of fibrinogen complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibrinogen-like protein 1
    Names
    hepassocin
    hepatocellular carcinoma-related sequence
    hepatocyte-derived fibrinogen-related protein 1
    liver fibrinogen-related protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004467.4 → NP_004458.3  fibrinogen-like protein 1 precursor

      See identical proteins and their annotated locations for NP_004458.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) appears to be the predominantly expressed transcript. It lacks an exon in the 5' UTR and has an alternate exon at the 5' end compared to the longest variant (4). All four variants encode the same protein.
      Source sequence(s)
      AC087273, AF042354, BG618053, D87342
      Consensus CDS
      CCDS6004.1
      UniProtKB/Swiss-Prot
      A6NKU4, Q08830, Q4PJH9, Q53YF1, Q8NG32, Q96KW6, Q96QM6
      Related
      ENSP00000401952.1, ENST00000427924.5
      Conserved Domains (1) summary
      cd00087
      Location:78 → 304
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    2. NM_147203.2 → NP_671736.2  fibrinogen-like protein 1 precursor

      See identical proteins and their annotated locations for NP_671736.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to the longest variant (4). All four variants encode the same protein.
      Source sequence(s)
      AF042354, BC007047, BG567956
      Consensus CDS
      CCDS6004.1
      UniProtKB/Swiss-Prot
      A6NKU4, Q08830, Q4PJH9, Q53YF1, Q8NG32, Q96KW6, Q96QM6
      Related
      ENSP00000371262.2, ENST00000381840.5
      Conserved Domains (1) summary
      cd00087
      Location:78 → 304
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    3. NM_201552.1 → NP_963846.1  fibrinogen-like protein 1 precursor

      See identical proteins and their annotated locations for NP_963846.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate exon at the 5' end compared to the longest variant (4). All four variants encode the same protein.
      Source sequence(s)
      AF042354, BC007047, BG566131, BG618053, D87342
      Consensus CDS
      CCDS6004.1
      UniProtKB/Swiss-Prot
      A6NKU4, Q08830, Q4PJH9, Q53YF1, Q8NG32, Q96KW6, Q96QM6
      Related
      ENSP00000371263.2, ENST00000381841.4
      Conserved Domains (1) summary
      cd00087
      Location:78 → 304
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    4. NM_201553.1 → NP_963847.1  fibrinogen-like protein 1 precursor

      See identical proteins and their annotated locations for NP_963847.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript. All four variants encode the same protein.
      Source sequence(s)
      AF042354, BG565379, BG567956, D87342
      Consensus CDS
      CCDS6004.1
      UniProtKB/Swiss-Prot
      A6NKU4, Q08830, Q4PJH9, Q53YF1, Q8NG32, Q96KW6, Q96QM6
      Related
      ENSP00000381131.1, ENST00000398054.5
      Conserved Domains (1) summary
      cd00087
      Location:78 → 304
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      17864389..17895538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421577.1 → XP_047277533.1  fibrinogen-like protein 1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      18131895..18183454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360131.1 → XP_054216106.1  fibrinogen-like protein 1 isoform X2

      UniProtKB/Swiss-Prot
      A6NKU4, Q08830, Q4PJH9, Q53YF1, Q8NG32, Q96KW6, Q96QM6

    2. XM_054360132.1 → XP_054216107.1  fibrinogen-like protein 1 isoform X1

    RNA

    1. XR_008487822.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08830.3 GenPept UniProtKB/Swiss-Prot:Q08830

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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