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    MCAT malonyl-CoA-acyl carrier protein transacylase [ Homo sapiens (human) ]

    Gene ID: 27349, updated on 10-Dec-2024

    Summary

    Official Symbol
    MCATprovided by HGNC
    Official Full Name
    malonyl-CoA-acyl carrier protein transacylaseprovided by HGNC
    Primary source
    HGNC:HGNC:29622
    See related
    Ensembl:ENSG00000100294 MIM:614479; AllianceGenome:HGNC:29622
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MT; MCT; MCT1; fabD; NET62; OPA15; FASN2C
    Summary
    The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2012]
    Expression
    Ubiquitous expression in kidney (RPKM 9.6), testis (RPKM 4.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MCAT in Genome Data Viewer
    Location:
    22q13.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (43132206..43143398, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (43613358..43624552, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (43528212..43539404, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S25 pseudogene 10 Neighboring gene Sharpr-MPRA regulatory region 7153 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:43506823-43507381 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19183 Neighboring gene BCL2 interacting killer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43524576-43525453 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63425 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13855 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19185 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43553089-43553609 Neighboring gene translocator protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43559052-43559555 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43559556-43560058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43564214-43565070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43565071-43565926 Neighboring gene tubulin tyrosine ligase like 12 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:43581791-43582295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19188 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13857 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13858

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC47838

    General protein information

    Preferred Names
    malonyl-CoA-acyl carrier protein transacylase, mitochondrial
    Names
    [Acyl-carrier-protein] malonyltransferase
    [acyl-carrier-protein] S-malonyltransferase
    malonyl CoA:ACP acyltransferase (mitochondrial)
    mitochondrial malonyl CoA:ACP acyltransferase
    mitochondrial malonyltransferase
    NP_055322.1
    NP_775738.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014507.3NP_055322.1  malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform b precursor

      See identical proteins and their annotated locations for NP_055322.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AI811069, AL359403, BI464466, BX111669, DB306307
      Consensus CDS
      CCDS14045.1
      UniProtKB/Swiss-Prot
      Q8IVS2
      Related
      ENSP00000331306.5, ENST00000327555.5
      Conserved Domains (1) summary
      cl08282
      Location:12171
      Acyl_transf_1; Acyl transferase domain
    2. NM_173467.5NP_775738.3  malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform a precursor

      See identical proteins and their annotated locations for NP_775738.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AI811069, AL022237, AL359401, BI464466, BX111669, DB306307
      Consensus CDS
      CCDS33660.1
      UniProtKB/Swiss-Prot
      B0QY72, O95510, O95511, Q8IVS2
      Related
      ENSP00000290429.5, ENST00000290429.11
      Conserved Domains (1) summary
      cl08282
      Location:12359
      Acyl_transf_1; Acyl transferase domain

    RNA

    1. NR_046423.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region, compared to variant 1, which results in a frameshift and an early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA402283, AI811069, AL359401, BI464466, BX111669, DB306307

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      43132206..43143398 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      43613358..43624552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)