U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    RRP1 ribosomal RNA processing 1 [ Homo sapiens (human) ]

    Gene ID: 8568, updated on 3-Dec-2024

    Summary

    Official Symbol
    RRP1provided by HGNC
    Official Full Name
    ribosomal RNA processing 1provided by HGNC
    Primary source
    HGNC:HGNC:18785
    See related
    Ensembl:ENSG00000160214 MIM:610653; AllianceGenome:HGNC:18785
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NNP-1; NOP52; RRP1A; D21S2056E
    Summary
    The protein encoded by this gene is the putative homolog of the yeast ribosomal RNA processing protein RRP1. The encoded protein is involved in the late stages of nucleologenesis at the end of mitosis, and may be required for the generation of 28S rRNA. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 8.5), testis (RPKM 8.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RRP1 in Genome Data Viewer
    Location:
    21q22.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (43789577..43805293)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (42145188..42160903)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (45209458..45225174)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45198401-45199200 Neighboring gene uncharacterized LOC105372825 Neighboring gene transmembrane protein 97 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45206281-45206822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45206823-45207363 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18548 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13370 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:45211808-45212020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45213337-45213836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45213839-45214490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18549 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18551 Neighboring gene apoptosis associated transcript in bladder cancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45230034-45230950 Neighboring gene uncharacterized LOC124905033

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of preribosome, small subunit precursor IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ribosomal RNA processing protein 1 homolog A
    Names
    Nnp1 homolog, nucleolar protein
    RRP1-like protein
    novel nuclear protein 1
    nucleolar protein Nop52
    protein NNP-1
    ribosomal RNA processing 1 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046959.1 RefSeqGene

      Range
      5043..20759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003683.6NP_003674.1  ribosomal RNA processing protein 1 homolog A

      See identical proteins and their annotated locations for NP_003674.1

      Status: REVIEWED

      Source sequence(s)
      AI634547, AP001053, BC000380, BI223794, DA275615
      Consensus CDS
      CCDS42951.1
      UniProtKB/Swiss-Prot
      P56182, Q9NST5
      UniProtKB/TrEMBL
      Q6PJJ2
      Related
      ENSP00000417464.1, ENST00000497547.2
      Conserved Domains (1) summary
      pfam05997
      Location:11219
      Nop52; Nucleolar protein,Nop52

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      43789577..43805293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017028485.3XP_016883974.1  ribosomal RNA processing protein 1 homolog A isoform X1

      UniProtKB/TrEMBL
      B4DZM3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      42145188..42160903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324893.1XP_054180868.1  ribosomal RNA processing protein 1 homolog A isoform X1

      UniProtKB/TrEMBL
      B4DZM3