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    GIRGL glutamine insufficiency regulator of glutaminase lncRNA [ Homo sapiens (human) ]

    Gene ID: 100506098, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GIRGLprovided by HGNC
    Official Full Name
    glutamine insufficiency regulator of glutaminase lncRNAprovided by HGNC
    Primary source
    HGNC:HGNC:55702
    See related
    Ensembl:ENSG00000233834 AllianceGenome:HGNC:55702
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MACC1-DT
    Expression
    Broad expression in small intestine (RPKM 3.7), kidney (RPKM 3.7) and 18 other tissues See more
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    Genomic context

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    See GIRGL in Genome Data Viewer
    Location:
    7p21.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (20217577..20221700)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (20351867..20355990)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (20257200..20261323)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927668 Neighboring gene uncharacterized LOC105375181 Neighboring gene NANOG hESC enhancer GRCh37_chr7:20156449-20156975 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:20159870-20160723 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:20160724-20161576 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:20164991-20165844 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:20165845-20166696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17988 Neighboring gene MACC1 antisense RNA 1 Neighboring gene MET transcriptional regulator MACC1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25688 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:20256832-20258031 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:20259517-20260046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17989 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25692 Neighboring gene uncharacterized LOC101927769 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:20369144-20369756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17990 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17991 Neighboring gene ITGB8 antisense RNA 1 Neighboring gene integrin subunit beta 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA GIRGL drives CAPRIN1-mediated phase separation to suppress glutaminase-1 translation under glutamine deprivation. Wang R, et al. Sci Adv, 2021 Mar. PMID 33762340, Free PMC Article
    2. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Low SK, et al. Cancer Sci, 2013 Aug. PMID 23648065, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Other Names

    • MACC1 divergent transcript

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_134567.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AI928513, BG777800, DR423379
      Related
      ENST00000738568.1

    2. NR_134568.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site, compared to variant 1.
      Source sequence(s)
      AI928513, BG777800, BI759100
      Related
      ENST00000738563.1

    3. NR_134569.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks a 5' exon and uses an alternate splice site, compared to variant 1.
      Source sequence(s)
      AI928513, BG777800
      Related
      ENST00000738564.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      20217577..20221700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      20351867..20355990
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials