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    TMEM273 transmembrane protein 273 [ Homo sapiens (human) ]

    Gene ID: 170371, updated on 27-Nov-2024

    Summary

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    Official Symbol
    TMEM273provided by HGNC
    Official Full Name
    transmembrane protein 273provided by HGNC
    Primary source
    HGNC:HGNC:27274
    See related
    Ensembl:ENSG00000204161 AllianceGenome:HGNC:27274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C10orf128
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in fat (RPKM 4.4), spleen (RPKM 4.0) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TMEM273 in Genome Data Viewer
    Location:
    10q11.23
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (49154736..49188391, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (50003603..50037281, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (50362781..50396436, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902545 Neighboring gene FAM170B antisense RNA 1 Neighboring gene family with sequence similarity 170 member B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50378847-50379346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50382921-50383422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50383423-50383922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3349 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:50451046-50451717 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50462512-50463040 Neighboring gene C10orf71 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:50505091-50505268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2361 Neighboring gene chromosome 10 open reading frame 71 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:50543527-50544726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50587592-50588092 Neighboring gene dorsal root ganglia homeobox

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. Wistow G, et al. Mol Vis, 2002 Jun 15. PMID 12107410
    2. A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition. Benslimane Y, et al. Aging Cell, 2021 Apr. PMID 33660365, Free PMC Article
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ52649

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 273

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010863.4 → NP_001010863.1  transmembrane protein 273 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001010863.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      BC031641, BC047724, BC104438, CA396219
      Consensus CDS
      CCDS41519.1
      UniProtKB/Swiss-Prot
      A6XND2, Q5T289, Q5T291, Q5T292
      Related
      ENSP00000417246.1, ENST00000474718.6
      Conserved Domains (1) summary
      pfam14986
      Location:15 → 74
      DUF4514; Domain of unknown function (DUF4514)

    2. NM_001288740.3 → NP_001275669.1  transmembrane protein 273 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001275669.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus.
      Source sequence(s)
      AL524299, BC031641, BC047724, CA396219
      Consensus CDS
      CCDS73128.1
      UniProtKB/TrEMBL
      A0A0A0MRR9
      Related
      ENSP00000363268.1, ENST00000374153.7
      Conserved Domains (1) summary
      pfam14986
      Location:15 → 74
      DUF4514; Domain of unknown function (DUF4514)

    3. NM_001288741.3 → NP_001275670.1  transmembrane protein 273 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC031641, BC047724, CA396219, DA366138
      Conserved Domains (1) summary
      pfam14986
      Location:15 → 74
      DUF4514; Domain of unknown function (DUF4514)

    4. NM_001288742.3 → NP_001275671.1  transmembrane protein 273 isoform 4

      See identical proteins and their annotated locations for NP_001275671.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon in the central coding region, which results in a frameshift, and uses an alternate splice site in the 3'-terminal exon, compared to variant 1. The encoded isoform (4) has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC031641, BC047724, BU145920, CA396219
      UniProtKB/TrEMBL
      Q5T290
      Related
      ENSP00000395067.1, ENST00000453436.5
      Conserved Domains (1) summary
      pfam14986
      Location:15 → 74
      DUF4514; Domain of unknown function (DUF4514)

    5. NM_001288743.3 → NP_001275672.1  transmembrane protein 273 isoform 5

      See identical proteins and their annotated locations for NP_001275672.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) includes an alternate exon in the central coding region, which results in a frameshift, and uses an alternate splice site in the 3'-terminal exon, compared to variant 1. The encoded isoform (5) has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC031641, BC047724, BU145920, CA396219, DQ884399
      UniProtKB/TrEMBL
      A0A0A0MRR9
      Related
      ENSP00000363266.4, ENST00000374151.7
      Conserved Domains (1) summary
      pfam14986
      Location:15 → 74
      DUF4514; Domain of unknown function (DUF4514)

    6. NM_001353330.2 → NP_001340259.1  transmembrane protein 273 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC084727, AL441885
      UniProtKB/TrEMBL
      A0AA34QVZ6
      Related
      ENSP00000516763.1, ENST00000707141.1
      Conserved Domains (1) summary
      pfam14986
      Location:15 → 74
      DUF4514; Domain of unknown function (DUF4514)

    7. NM_001353331.2 → NP_001340260.1  transmembrane protein 273 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AC084727, AL441885
      Conserved Domains (1) summary
      pfam14986
      Location:15 → 74
      DUF4514; Domain of unknown function (DUF4514)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      49154736..49188391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017015797.2 → XP_016871286.1  transmembrane protein 273 isoform X10

      Conserved Domains (1) summary
      pfam14986
      Location:15 → 74
      DUF4514; Domain of unknown function (DUF4514)

    2. XM_011539385.2 → XP_011537687.1  transmembrane protein 273 isoform X15

      Conserved Domains (1) summary
      pfam14986
      Location:15 → 74
      DUF4514; Domain of unknown function (DUF4514)

    3. XM_017015794.2 → XP_016871283.1  transmembrane protein 273 isoform X8

      Conserved Domains (1) summary
      pfam14986
      Location:15 → 74
      DUF4514; Domain of unknown function (DUF4514)

    4. XM_011539384.2 → XP_011537686.1  transmembrane protein 273 isoform X14

      Conserved Domains (1) summary
      pfam14986
      Location:15 → 74
      DUF4514; Domain of unknown function (DUF4514)

    5. XM_047424684.1 → XP_047280640.1  transmembrane protein 273 isoform X4

    6. XM_047424687.1 → XP_047280643.1  transmembrane protein 273 isoform X7

    7. XM_047424685.1 → XP_047280641.1  transmembrane protein 273 isoform X13

    8. XM_017015793.2 → XP_016871282.1  transmembrane protein 273 isoform X3

      Conserved Domains (1) summary
      pfam14986
      Location:15 → 74
      DUF4514; Domain of unknown function (DUF4514)

    9. XM_017015792.2 → XP_016871281.1  transmembrane protein 273 isoform X1

      Conserved Domains (1) summary
      pfam14986
      Location:15 → 74
      DUF4514; Domain of unknown function (DUF4514)

    10. XM_011539379.2 → XP_011537681.1  transmembrane protein 273 isoform X12

      Conserved Domains (1) summary
      pfam14986
      Location:15 → 74
      DUF4514; Domain of unknown function (DUF4514)

    11. XM_024447853.2 → XP_024303621.1  transmembrane protein 273 isoform X11

      Conserved Domains (1) summary
      pfam14986
      Location:15 → 74
      DUF4514; Domain of unknown function (DUF4514)

    12. XM_011539382.2 → XP_011537684.1  transmembrane protein 273 isoform X5

      Conserved Domains (1) summary
      pfam14986
      Location:15 → 74
      DUF4514; Domain of unknown function (DUF4514)

    13. XM_047424686.1 → XP_047280642.1  transmembrane protein 273 isoform X6

    14. XM_011539378.3 → XP_011537680.1  transmembrane protein 273 isoform X2

      Conserved Domains (1) summary
      pfam14986
      Location:15 → 74
      DUF4514; Domain of unknown function (DUF4514)

    15. XM_017015796.2 → XP_016871285.1  transmembrane protein 273 isoform X9

      Conserved Domains (1) summary
      pfam14986
      Location:15 → 74
      DUF4514; Domain of unknown function (DUF4514)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      50003603..50037281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364936.1 → XP_054220911.1  transmembrane protein 273 isoform X10

    2. XM_054364934.1 → XP_054220909.1  transmembrane protein 273 isoform X8

    3. XM_054364930.1 → XP_054220905.1  transmembrane protein 273 isoform X4

    4. XM_054364933.1 → XP_054220908.1  transmembrane protein 273 isoform X7

    5. XM_054364929.1 → XP_054220904.1  transmembrane protein 273 isoform X3

    6. XM_054364927.1 → XP_054220902.1  transmembrane protein 273 isoform X1

    7. XM_054364937.1 → XP_054220912.1  transmembrane protein 273 isoform X11

    8. XM_054364931.1 → XP_054220906.1  transmembrane protein 273 isoform X5

    9. XM_054364932.1 → XP_054220907.1  transmembrane protein 273 isoform X6

    10. XM_054364928.1 → XP_054220903.1  transmembrane protein 273 isoform X2

    11. XM_054364935.1 → XP_054220910.1  transmembrane protein 273 isoform X9

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5T292.1 GenPept UniProtKB/Swiss-Prot:Q5T292

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