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    PELATON plaque enriched lncRNA in atherosclerotic and inflammatory bowel macrophage regulation [ Homo sapiens (human) ]

    Gene ID: 100506115, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PELATONprovided by HGNC
    Official Full Name
    plaque enriched lncRNA in atherosclerotic and inflammatory bowel macrophage regulationprovided by HGNC
    Primary source
    HGNC:HGNC:50328
    See related
    Ensembl:ENSG00000224397 AllianceGenome:HGNC:50328
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GCRL1; SMIM25; LINC01272
    Expression
    Biased expression in appendix (RPKM 11.9), lung (RPKM 11.2) and 6 other tissues See more
    Orthologs
    all
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    Genomic context

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    See PELATON in Genome Data Viewer
    Location:
    20q13.13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (50267478..50279788)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (52037180..52049490)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (48884015..48896325)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985386 Neighboring gene uncharacterized LOC105372656 Neighboring gene MPRA-validated peak4248 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48891163-48891664 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48891665-48892164 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48894009-48894546 Neighboring gene Sharpr-MPRA regulatory region 10045 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13019 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48908810-48909546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48910660-48911160 Neighboring gene long intergenic non-protein coding RNA 1270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48921517-48922292 Neighboring gene Sharpr-MPRA regulatory region 5066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48925071-48925582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48925583-48926093 Neighboring gene long intergenic non-protein coding RNA 1271 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48937461-48938045 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48938046-48938631 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48938632-48939216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18086 Neighboring gene uncharacterized LOC105372657 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:48971862-48972074

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. High expression of lncRNA PELATON serves as a risk factor for the incidence and prognosis of acute coronary syndrome. Chen L, et al. Sci Rep, 2022 May 16. PMID 35577857, Free PMC Article
    2. Novel Plaque Enriched Long Noncoding RNA in Atherosclerotic Macrophage Regulation (PELATON). Hung J, et al. Arterioscler Thromb Vasc Biol, 2020 Mar. PMID 31826651, Free PMC Article
    3. Discovery of PELATON links to the INHBA gene in the TGF-β pathway in colorectal cancer using a combination of bioinformatics and experimental investigations. Abutalebi M, et al. Int J Biol Macromol, 2024 Jun. PMID 38735606
    4. LINC01018 and SMIM25 sponged miR-182-5p in endometriosis revealed by the ceRNA network construction. Jiang L, et al. Int J Immunopathol Pharmacol, 2020 Jan-Dec. PMID 33237828, Free PMC Article
    5. Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease. Haberman Y, et al. Inflamm Bowel Dis, 2018 Jan 18. PMID 29361088, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Discovery of PELATON links to the INHBA gene in the TGF-beta pathway in colorectal cancer using a combination of bioinformatics and experimental investigations.
      Title: Discovery of PELATON links to the INHBA gene in the TGF-β pathway in colorectal cancer using a combination of bioinformatics and experimental investigations.
    2. High expression of lncRNA PELATON serves as a risk factor for the incidence and prognosis of acute coronary syndrome.
      Title: High expression of lncRNA PELATON serves as a risk factor for the incidence and prognosis of acute coronary syndrome.
    3. LINC01272 Suppressed Cell Multiplication and Induced Apoptosis Via Regulating MiR-7-5p/CRLS1 Axis in Lung Cancer.
      Title: LINC01272 Suppressed Cell Multiplication and Induced Apoptosis Via Regulating MiR-7-5p/CRLS1 Axis in Lung Cancer.
    4. LINC01018 and SMIM25 sponged miR-182-5p in endometriosis revealed by the ceRNA network construction.
      Title: LINC01018 and SMIM25 sponged miR-182-5p in endometriosis revealed by the ceRNA network construction.
    5. PELATON is a nuclear expressed, monocyte- and macrophage-specific lncRNA, upregulated in unstable atherosclerotic plaque.
      Title: Novel Plaque Enriched Long Noncoding RNA in Atherosclerotic Macrophage Regulation (PELATON).
    6. Co-expression and functional annotation enrichment analyses across several tissues and cell types showed that the upregulated LINC01272 is associated with a myeloid pro-inflammatory signature, whereas the downregulated HNF4A-AS1 exhibits association with an epithelial metabolic signature. The study identified significant correlations between LINC01272 and HNF4A-AS1 expression and more severe mucosal injury.
      Title: Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease.
    7. there were significantly positive correlations in KIF9AS1, LINC01272 and DIO3OS expression between IBD tissue and plasma samples. Therefore, the present study indicated that KIF9AS1, LINC01272 and DIO3OS may be potential diagnostic biomarkers for IBD.
      Title: KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Other Names

    • GC-related lncRNA1
    • long intergenic non-protein coding RNA 1272
    • small integral membrane protein 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_170991.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL354889
      Related
      ENST00000425497.6

    2. NR_170992.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL354889
      Related
      ENST00000622604.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      50267478..50279788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      52037180..52049490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001278655.2: Suppressed sequence

      Description
      NM_001278655.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.
    Nucleotide Protein
    Heading Accession and Version

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