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    ZNF286A zinc finger protein 286A [ Homo sapiens (human) ]

    Gene ID: 57335, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF286Aprovided by HGNC
    Official Full Name
    zinc finger protein 286Aprovided by HGNC
    Primary source
    HGNC:HGNC:13501
    See related
    Ensembl:ENSG00000187607 AllianceGenome:HGNC:13501
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF286
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 4.0), endometrium (RPKM 3.2) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF286A in Genome Data Viewer
    Location:
    17p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (15699752..15720787)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (15605992..15627027)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (15603066..15624101)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene proximal CMT1A-REP Neighboring gene F-box and WD repeat domain containing 10B Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:15495673-15496196 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15545644-15546230 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15546231-15546817 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:15547662-15548477 Neighboring gene tripartite motif containing 16 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11743 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15554223-15555172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:15562775-15563277 Neighboring gene ZNF286A-TBC1D26 readthrough (NMD candidate) Neighboring gene zinc finger protein 29, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:15602763-15603374 Neighboring gene ubiquitin conjugating enzyme E2 S pseudogene 1 Neighboring gene TBC1D26 antisense RNA 1 Neighboring gene uncharacterized LOC105371559 Neighboring gene TBC1 domain family member 26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Isolation of novel genes from the CMT1A duplication/HNPP deletion critical region in 17p11.2-p12. Murakami T, et al. Genomics, 1997 Jan 1. PMID 9027492
    2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2001 Apr 27. PMID 11347906
    3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. Nakajima D, et al. DNA Res, 2002 Jun 30. PMID 12168954
    4. Assessment of community efforts to advance network-based prediction of protein-protein interactions. Wang XW, et al. Nat Commun, 2023 Mar 22. PMID 36949045, Free PMC Article
    5. PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα. Ramberger E, et al. iScience, 2021 Jun 25. PMID 34189442, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1874, MGC149627, MGC156181

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 286A
    Names
    zinc finger protein ZNF286

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130842.2 → NP_001124314.1  zinc finger protein 286A isoform 2

      See identical proteins and their annotated locations for NP_001124314.1

      Status: VALIDATED

      Source sequence(s)
      AC005324, AF217226, AK315062, BU687070
      Consensus CDS
      CCDS11172.1
      UniProtKB/Swiss-Prot
      B4DKF9, Q96JF3, Q9HBT8
      Related
      ENSP00000464063.1, ENST00000583566.6
      Conserved Domains (6) summary
      smart00349
      Location:45 → 98
      KRAB; krueppel associated box
      COG5048
      Location:352 → 507
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:384 → 404
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:354 → 376
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:45 → 80
      KRAB; KRAB box
      pfam13465
      Location:424 → 449
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001288642.2 → NP_001275571.1  zinc finger protein 286A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005324
      UniProtKB/Swiss-Prot
      Q9HBT8
      Conserved Domains (6) summary
      smart00349
      Location:88 → 141
      KRAB; krueppel associated box
      COG5048
      Location:395 → 550
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:427 → 447
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:397 → 419
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:88 → 123
      KRAB; KRAB box
      pfam13465
      Location:467 → 492
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001288643.2 → NP_001275572.1  zinc finger protein 286A isoform 3

      See identical proteins and their annotated locations for NP_001275572.1

      Status: VALIDATED

      Source sequence(s)
      AC005324
      Consensus CDS
      CCDS73997.1
      UniProtKB/Swiss-Prot
      Q9HBT8
      Related
      ENSP00000466154.1, ENST00000593105.5
      Conserved Domains (6) summary
      smart00349
      Location:35 → 88
      KRAB; krueppel associated box
      COG5048
      Location:342 → 497
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:374 → 394
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:344 → 366
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:35 → 70
      KRAB; KRAB box
      pfam13465
      Location:414 → 439
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001288644.2 → NP_001275573.2  zinc finger protein 286A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC005324
      UniProtKB/TrEMBL
      A1A525
      Conserved Domains (2) summary
      COG5048
      Location:240 → 395
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001288645.2 → NP_001275574.1  zinc finger protein 286A isoform 5

      See identical proteins and their annotated locations for NP_001275574.1

      Status: VALIDATED

      Source sequence(s)
      AC005324
      UniProtKB/TrEMBL
      A1A525
      Conserved Domains (2) summary
      COG5048
      Location:240 → 395
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001288646.2 → NP_001275575.1  zinc finger protein 286A isoform 5

      See identical proteins and their annotated locations for NP_001275575.1

      Status: VALIDATED

      Source sequence(s)
      AC005324
      UniProtKB/TrEMBL
      A1A525
      Conserved Domains (2) summary
      COG5048
      Location:240 → 395
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_001288647.2 → NP_001275576.1  zinc finger protein 286A isoform 5

      See identical proteins and their annotated locations for NP_001275576.1

      Status: VALIDATED

      Source sequence(s)
      AC005324
      UniProtKB/TrEMBL
      A1A525
      Conserved Domains (2) summary
      COG5048
      Location:240 → 395
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. NM_001288648.2 → NP_001275577.1  zinc finger protein 286A isoform 5

      See identical proteins and their annotated locations for NP_001275577.1

      Status: VALIDATED

      Source sequence(s)
      AC005324
      UniProtKB/TrEMBL
      A1A525
      Conserved Domains (2) summary
      COG5048
      Location:240 → 395
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. NM_001288649.2 → NP_001275578.1  zinc finger protein 286A isoform 5

      See identical proteins and their annotated locations for NP_001275578.1

      Status: VALIDATED

      Source sequence(s)
      AC005324
      UniProtKB/TrEMBL
      A1A525
      Conserved Domains (2) summary
      COG5048
      Location:240 → 395
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    10. NM_001369436.1 → NP_001356365.1  zinc finger protein 286A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC005324
      UniProtKB/TrEMBL
      A1A525
      Conserved Domains (2) summary
      COG5048
      Location:240 → 395
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    11. NM_001369437.1 → NP_001356366.1  zinc finger protein 286A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC005324
      UniProtKB/TrEMBL
      A1A525
      Conserved Domains (2) summary
      COG5048
      Location:240 → 395
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    12. NM_001369438.1 → NP_001356367.1  zinc finger protein 286A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC005324
      UniProtKB/TrEMBL
      A1A525
      Conserved Domains (2) summary
      COG5048
      Location:240 → 395
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    13. NM_001369440.1 → NP_001356369.1  zinc finger protein 286A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC005324
      Conserved Domains (3) summary
      smart00349
      Location:1 → 47
      KRAB; krueppel associated box
      COG5048
      Location:301 → 456
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:333 → 353
      ZF_C2H2; C2H2 Zn finger [structural motif]

    14. NM_020652.3 → NP_065703.1  zinc finger protein 286A isoform 2

      See identical proteins and their annotated locations for NP_065703.1

      Status: VALIDATED

      Source sequence(s)
      AC005324
      Consensus CDS
      CCDS11172.1
      UniProtKB/Swiss-Prot
      B4DKF9, Q96JF3, Q9HBT8
      Related
      ENSP00000397163.1, ENST00000421016.5
      Conserved Domains (6) summary
      smart00349
      Location:45 → 98
      KRAB; krueppel associated box
      COG5048
      Location:352 → 507
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:384 → 404
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:354 → 376
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:45 → 80
      KRAB; KRAB box
      pfam13465
      Location:424 → 449
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      15699752..15720787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      15605992..15627027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HBT8.1 GenPept UniProtKB/Swiss-Prot:Q9HBT8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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