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    Ptpn14 protein tyrosine phosphatase, non-receptor type 14 [ Mus musculus (house mouse) ]

    Gene ID: 19250, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptpn14provided by MGI
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 14provided by MGI
    Primary source
    MGI:MGI:102467
    See related
    Ensembl:ENSMUSG00000026604 AllianceGenome:MGI:102467
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PTP36; C130080N23Rik
    Summary
    Predicted to enable protein tyrosine phosphatase activity; receptor tyrosine kinase binding activity; and transcription coregulator activity. Involved in lymphangiogenesis. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; musculoskeletal system; and sensory organ. Orthologous to human PTPN14 (protein tyrosine phosphatase non-receptor type 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 7.4), lung adult (RPKM 7.1) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ptpn14 in Genome Data Viewer
    Location:
    1 H6; 1 95.03 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (189460417..189608892)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (189728216..189876695)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3351 Neighboring gene predicted gene, 30088 Neighboring gene centromere protein F Neighboring gene STARR-positive B cell enhancer ABC_E802 Neighboring gene STARR-positive B cell enhancer mm9_chr1:191524821-191525121 Neighboring gene STARR-seq mESC enhancer starr_03400 Neighboring gene STARR-seq mESC enhancer starr_03401 Neighboring gene STARR-seq mESC enhancer starr_03402 Neighboring gene predicted gene, 51739 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:191627745-191627946 Neighboring gene STARR-seq mESC enhancer starr_03406 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:191654884-191655189 Neighboring gene STARR-seq mESC enhancer starr_03408 Neighboring gene STARR-seq mESC enhancer starr_03409 Neighboring gene predicted gene, 30280 Neighboring gene predicted gene, 26574 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:191691042-191691151 Neighboring gene STARR-seq mESC enhancer starr_03412 Neighboring gene SET and MYND domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_03413 Neighboring gene STARR-positive B cell enhancer mm9_chr1:191796963-191797263 Neighboring gene predicted gene, 39736

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Gene trapped (2) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coregulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lymphangiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lymphangiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lymphangiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein phosphatase non-receptor type 14
    Names
    protein-tyrosine phosphatase PTP36
    NP_033002.2
    XP_006497192.1
    XP_006497194.1
    XP_006497196.1
    XP_006497197.1
    XP_030108157.1
    XP_036018685.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008976.2NP_033002.2  tyrosine-protein phosphatase non-receptor type 14

      See identical proteins and their annotated locations for NP_033002.2

      Status: VALIDATED

      Source sequence(s)
      AC140250, AC140461, AK037646, AK136544, BB663191, CK780322, DV552967
      Consensus CDS
      CCDS15609.1
      UniProtKB/Swiss-Prot
      G5E8M1, Q62130
      UniProtKB/TrEMBL
      Q8CAV9
      Related
      ENSMUSP00000095051.3, ENSMUST00000097442.9
      Conserved Domains (3) summary
      smart00295
      Location:24220
      B41; Band 4.1 homologues
      cd13188
      Location:215305
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      cd14599
      Location:8981184
      PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      189460417..189608892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497134.4XP_006497197.1  tyrosine-protein phosphatase non-receptor type 14 isoform X2

      Conserved Domains (3) summary
      cd13188
      Location:116206
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      cd14599
      Location:7991085
      PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14
      pfam00373
      Location:6121
      FERM_M; FERM central domain
    2. XM_036162792.1XP_036018685.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

      UniProtKB/Swiss-Prot
      G5E8M1, Q62130
      UniProtKB/TrEMBL
      Q8CAV9
      Conserved Domains (3) summary
      smart00295
      Location:24220
      B41; Band 4.1 homologues
      cd13188
      Location:215305
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      cd14599
      Location:8981184
      PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14
    3. XM_006497131.5XP_006497194.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

      See identical proteins and their annotated locations for XP_006497194.1

      UniProtKB/Swiss-Prot
      G5E8M1, Q62130
      UniProtKB/TrEMBL
      Q8CAV9
      Conserved Domains (3) summary
      smart00295
      Location:24220
      B41; Band 4.1 homologues
      cd13188
      Location:215305
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      cd14599
      Location:8981184
      PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14
    4. XM_030252297.2XP_030108157.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

      UniProtKB/Swiss-Prot
      G5E8M1, Q62130
      UniProtKB/TrEMBL
      Q8CAV9
      Conserved Domains (3) summary
      smart00295
      Location:24220
      B41; Band 4.1 homologues
      cd13188
      Location:215305
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      cd14599
      Location:8981184
      PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14
    5. XM_006497129.5XP_006497192.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

      See identical proteins and their annotated locations for XP_006497192.1

      UniProtKB/Swiss-Prot
      G5E8M1, Q62130
      UniProtKB/TrEMBL
      Q8CAV9
      Conserved Domains (3) summary
      smart00295
      Location:24220
      B41; Band 4.1 homologues
      cd13188
      Location:215305
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      cd14599
      Location:8981184
      PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14
    6. XM_006497133.5XP_006497196.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

      See identical proteins and their annotated locations for XP_006497196.1

      UniProtKB/Swiss-Prot
      G5E8M1, Q62130
      UniProtKB/TrEMBL
      Q8CAV9
      Conserved Domains (3) summary
      smart00295
      Location:24220
      B41; Band 4.1 homologues
      cd13188
      Location:215305
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      cd14599
      Location:8981184
      PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033287.1: Suppressed sequence

      Description
      NM_001033287.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.