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    Top2b topoisomerase (DNA) II beta [ Mus musculus (house mouse) ]

    Gene ID: 21974, updated on 9-Dec-2024

    Summary

    Official Symbol
    Top2bprovided by MGI
    Official Full Name
    topoisomerase (DNA) II betaprovided by MGI
    Primary source
    MGI:MGI:98791
    See related
    Ensembl:ENSMUSG00000017485 AllianceGenome:MGI:98791
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Top-2; D230016L12Rik
    Summary
    Enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Involved in B cell differentiation. Acts upstream of or within axonogenesis; forebrain development; and neuron migration. Located in nucleus. Is expressed in central nervous system; genitourinary system; and retina. Orthologous to human TOP2B (DNA topoisomerase II beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 40.7), CNS E14 (RPKM 36.8) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Top2b in Genome Data Viewer
    Location:
    14 A1; 14 7.08 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (6038976..6104585, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (16365206..16430787)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene retinoic acid receptor, beta Neighboring gene ATP-binding cassette, sub-family E (OABP), member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36026 Neighboring gene predicted gene, 53820 Neighboring gene predicted gene, 46442 Neighboring gene STARR-seq mESC enhancer starr_36025 Neighboring gene STARR-positive B cell enhancer ABC_E1166 Neighboring gene STARR-seq mESC enhancer starr_36024 Neighboring gene STARR-seq mESC enhancer starr_36023 Neighboring gene STARR-seq mESC enhancer starr_36022 Neighboring gene N-glycanase 1 Neighboring gene ribosomal protein L31, pseudogene 3 Neighboring gene 3-oxoacyl-ACP synthase, mitochondrial

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA negative supercoiling activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA topoisomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribonucleoprotein complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA topological change ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA topological change ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to ATP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular senescence IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of double-strand break repair via nonhomologous end joining IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of single stranded viral RNA replication via double stranded DNA intermediate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of single stranded viral RNA replication via double stranded DNA intermediate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    NOT located_in chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    DNA topoisomerase 2-beta
    Names
    DNA topoisomerase II, beta isozyme
    NP_033435.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009409.3NP_033435.2  DNA topoisomerase 2-beta

      See identical proteins and their annotated locations for NP_033435.2

      Status: VALIDATED

      Source sequence(s)
      AC154452, AC154471
      Consensus CDS
      CCDS26833.1
      UniProtKB/Swiss-Prot
      Q64511, Q7TQG4
      Related
      ENSMUSP00000017629.5, ENSMUST00000017629.12
      Conserved Domains (8) summary
      cd03365
      Location:464584
      TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
      PHA03151
      Location:13441582
      PHA03151; hypothetical protein; Provisional
      cd00187
      Location:7201180
      TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
      cd03481
      Location:274426
      TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
      PTZ00108
      Location:341457
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam02518
      Location:89186
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
      pfam08070
      Location:14951596
      DTHCT; DTHCT (NUC029) region
      pfam16898
      Location:582720
      TOPRIM_C; C-terminal associated domain of TOPRIM

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      6038976..6104585 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)