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    Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease [ Mus musculus (house mouse) ]

    Gene ID: 72662, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dis3provided by MGI
    Official Full Name
    DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonucleaseprovided by MGI
    Primary source
    MGI:MGI:1919912
    See related
    Ensembl:ENSMUSG00000033166 AllianceGenome:MGI:1919912
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810028N01Rik
    Summary
    Predicted to enable 3'-5'-RNA exonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in RNA metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Is expressed in renal cortex; telencephalon ventricular layer; and thymus primordium. Orthologous to human DIS3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.1), limb E14.5 (RPKM 5.2) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dis3 in Genome Data Viewer
    Location:
    14 E2.2; 14 49.25 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (99314070..99337217, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (99076634..99099780, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36A, pseudogene 1 Neighboring gene VISTA enhancer mm829 Neighboring gene STARR-seq mESC enhancer starr_37425 Neighboring gene STARR-positive B cell enhancer ABC_E1902 Neighboring gene mitotic spindle organizing protein 1 Neighboring gene bora, aurora kinase A activator Neighboring gene STARR-positive B cell enhancer ABC_E5462 Neighboring gene STARR-seq mESC enhancer starr_37426 Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene STARR-seq mESC enhancer starr_37427 Neighboring gene STARR-seq mESC enhancer starr_37430 Neighboring gene STARR-seq mESC enhancer starr_37436 Neighboring gene Kruppel-like transcription factor 5 Neighboring gene STARR-seq mESC enhancer starr_37437 Neighboring gene predicted gene, 22984

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3'-5'-RNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3'-5'-RNA exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables endonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in CUT catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in CUT catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear mRNA surveillance of mRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in rRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in rRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear exosome (RNase complex) ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of nuclear exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    exosome complex exonuclease RRP44
    Names
    DIS3 mitotic control homolog
    protein DIS3 homolog
    ribosomal RNA-processing protein 44

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360050.1NP_001346979.1  exosome complex exonuclease RRP44 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154843, AK032091, AK038313, CN705423
      Conserved Domains (2) summary
      COG0557
      Location:101836
      VacB; Exoribonuclease R [Transcription]
      cl14812
      Location:1103
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    2. NM_001360051.1NP_001346980.1  exosome complex exonuclease RRP44 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154843, AK032091, AK038313, CN705423
      Conserved Domains (1) summary
      COG0557
      Location:2741
      VacB; Exoribonuclease R [Transcription]
    3. NM_028315.2NP_082591.2  exosome complex exonuclease RRP44 isoform 1

      See identical proteins and their annotated locations for NP_082591.2

      Status: VALIDATED

      Source sequence(s)
      AC154843, AK012840, AK032091, CJ176790, CN705423
      Consensus CDS
      CCDS49555.1
      UniProtKB/Swiss-Prot
      Q6ZQ07, Q8C074, Q9CSH3
      Related
      ENSMUSP00000041906.10, ENSMUST00000042471.11
      Conserved Domains (3) summary
      cd09862
      Location:9197
      PIN_Rrp44; PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
      COG0557
      Location:195930
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:467795
      RNB; RNB domain

    RNA

    1. NR_153390.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154843, AK012840, AK032091, AK038313, CN705423
      Related
      ENSMUST00000228643.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      99314070..99337217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519602.5XP_006519665.1  exosome complex exonuclease RRP44 isoform X3

      Conserved Domains (2) summary
      COG0557
      Location:165900
      VacB; Exoribonuclease R [Transcription]
      cd09862
      Location:9167
      PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
    2. XM_030248047.1XP_030103907.1  exosome complex exonuclease RRP44 isoform X1

      Conserved Domains (1) summary
      COG0557
      Location:2741
      VacB; Exoribonuclease R [Transcription]
    3. XM_017316212.3XP_017171701.1  exosome complex exonuclease RRP44 isoform X2

      UniProtKB/TrEMBL
      A0A2I3BR78
      Conserved Domains (2) summary
      cd09862
      Location:9197
      PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
      cl39058
      Location:195545
      RNB; RNB domain