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    Rapgef3 Rap guanine nucleotide exchange factor (GEF) 3 [ Mus musculus (house mouse) ]

    Gene ID: 223864, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rapgef3provided by MGI
    Official Full Name
    Rap guanine nucleotide exchange factor (GEF) 3provided by MGI
    Primary source
    MGI:MGI:2441741
    See related
    Ensembl:ENSMUSG00000022469 AllianceGenome:MGI:2441741
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Epac; Epac1; 2310016P22Rik; 9330170P05Rik
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in associative learning. Predicted to be located in several cellular components, including basolateral part of cell; brush border membrane; and distal axon. Predicted to be active in plasma membrane. Is expressed in brain; heart; lens; lung; and metanephros. Orthologous to human RAPGEF3 (Rap guanine nucleotide exchange factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in kidney adult (RPKM 30.5), thymus adult (RPKM 25.7) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rapgef3 in Genome Data Viewer
    Location:
    15 F1; 15 53.74 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (97637886..97666300, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (97744770..97768419, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RNA polymerase II associated protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E7415 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97551732-97551973 Neighboring gene endonuclease, polyU-specific Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97561501-97561858 Neighboring gene STARR-positive B cell enhancer ABC_E5512 Neighboring gene STARR-positive B cell enhancer ABC_E2450 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97580414-97580523 Neighboring gene predicted gene, 33531 Neighboring gene STARR-seq mESC enhancer starr_39638 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 3, opposite strand 2 Neighboring gene STARR-positive B cell enhancer ABC_E5513 Neighboring gene predicted gene, 46535 Neighboring gene solute carrier family 48 (heme transporter), member 1 Neighboring gene histone deacetylase 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (14)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC19192

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cAMP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cAMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Rap protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Rap protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in associative learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to cAMP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cAMP ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of endothelial barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of syncytium formation by plasma membrane fusion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of syncytium formation by plasma membrane fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein export from nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stress fiber assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of syncytium formation by plasma membrane fusion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of syncytium formation by plasma membrane fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microvillus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in photoreceptor cell terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ribbon synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in rod bipolar cell terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rap guanine nucleotide exchange factor 3
    Names
    Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
    cAMP-GEFI
    cAMP-regulated guanine nucleotide exchange factor I
    exchange protein directly activated by cAMP 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177810.1NP_001171281.1  rap guanine nucleotide exchange factor 3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (1).
      Source sequence(s)
      AC104225, AK034265, AK142594, CJ051320
      Consensus CDS
      CCDS49714.1
      UniProtKB/TrEMBL
      Q3UQC2
      Related
      ENSMUSP00000116426.3, ENSMUST00000126854.9
      Conserved Domains (4) summary
      smart00147
      Location:661926
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:247356
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:100223
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:387496
      RasGEF_N; RasGEF N-terminal motif
    2. NM_001177811.1NP_001171282.1  rap guanine nucleotide exchange factor 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AC104225, AK034265, AK169430, CJ051320
      Consensus CDS
      CCDS49713.1
      UniProtKB/TrEMBL
      E9Q2E5, Q3TES7
      Related
      ENSMUSP00000120126.3, ENSMUST00000128775.9
      Conserved Domains (5) summary
      cd06224
      Location:392513
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:661909
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      COG0664
      Location:268346
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:247356
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:100223
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    3. NM_001357630.1NP_001344559.1  rap guanine nucleotide exchange factor 3 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 4.
      Source sequence(s)
      AC104225
      UniProtKB/TrEMBL
      Q3UQC2
      Conserved Domains (4) summary
      cd06224
      Location:392513
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:661929
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:247356
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:100223
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    4. NM_144850.2NP_659099.2  rap guanine nucleotide exchange factor 3 isoform 2

      See identical proteins and their annotated locations for NP_659099.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC104225
      Consensus CDS
      CCDS37187.2
      UniProtKB/Swiss-Prot
      Q8BZK9, Q8R1R1, Q8VCC8
      UniProtKB/TrEMBL
      Q3UQC2
      Related
      ENSMUSP00000118148.3, ENSMUST00000129223.9
      Conserved Domains (5) summary
      cd06224
      Location:392513
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:661918
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      COG0664
      Location:268346
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:247356
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:100223
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      97637886..97666300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248523.2XP_030104383.1  rap guanine nucleotide exchange factor 3 isoform X9

      UniProtKB/TrEMBL
      Q3UQC2
      Conserved Domains (4) summary
      smart00147
      Location:661926
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:247356
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:100223
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:387496
      RasGEF_N; RasGEF N-terminal motif
    2. XM_036159382.1XP_036015275.1  rap guanine nucleotide exchange factor 3 isoform X14

      UniProtKB/TrEMBL
      H3BK39
      Conserved Domains (4) summary
      smart00147
      Location:568833
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:154263
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00618
      Location:294403
      RasGEF_N; RasGEF N-terminal motif
      cl02442
      Location:36130
      DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
    3. XM_036159375.1XP_036015268.1  rap guanine nucleotide exchange factor 3 isoform X2

      UniProtKB/TrEMBL
      Q3UQC2
      Conserved Domains (4) summary
      smart00147
      Location:695960
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:281390
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:131257
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:421530
      RasGEF_N; RasGEF N-terminal motif
    4. XM_017316583.3XP_017172072.1  rap guanine nucleotide exchange factor 3 isoform X4

      UniProtKB/TrEMBL
      Q3UQC2
      Related
      ENSMUSP00000135238.2, ENSMUST00000177352.8
      Conserved Domains (4) summary
      smart00147
      Location:692957
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:278387
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:131254
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:418527
      RasGEF_N; RasGEF N-terminal motif
    5. XM_017316585.2XP_017172074.1  rap guanine nucleotide exchange factor 3 isoform X17

      Conserved Domains (2) summary
      smart00147
      Location:233498
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cl02520
      Location:185
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    6. XM_030248524.1XP_030104384.1  rap guanine nucleotide exchange factor 3 isoform X10

      UniProtKB/TrEMBL
      Q3UQC2
      Conserved Domains (4) summary
      smart00147
      Location:661915
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:247356
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:100223
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:387496
      RasGEF_N; RasGEF N-terminal motif
    7. XM_036159379.1XP_036015272.1  rap guanine nucleotide exchange factor 3 isoform X8

      UniProtKB/TrEMBL
      Q3UQC2
      Conserved Domains (4) summary
      smart00147
      Location:664932
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:250359
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:100226
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:390499
      RasGEF_N; RasGEF N-terminal motif
    8. XM_036159378.1XP_036015271.1  rap guanine nucleotide exchange factor 3 isoform X8

      UniProtKB/TrEMBL
      Q3UQC2
      Conserved Domains (4) summary
      smart00147
      Location:664932
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:250359
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:100226
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:390499
      RasGEF_N; RasGEF N-terminal motif
    9. XM_036159381.1XP_036015274.1  rap guanine nucleotide exchange factor 3 isoform X13

      UniProtKB/TrEMBL
      H3BK39
      Conserved Domains (4) summary
      smart00147
      Location:571839
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:157266
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00618
      Location:297406
      RasGEF_N; RasGEF N-terminal motif
      cl02442
      Location:36133
      DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
    10. XM_011245602.4XP_011243904.1  rap guanine nucleotide exchange factor 3 isoform X12

      UniProtKB/TrEMBL
      H3BK39
      Conserved Domains (4) summary
      smart00147
      Location:619887
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:205314
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:58181
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:345454
      RasGEF_N; RasGEF N-terminal motif
    11. XM_036159380.1XP_036015273.1  rap guanine nucleotide exchange factor 3 isoform X11

      UniProtKB/TrEMBL
      H3BK39
      Conserved Domains (4) summary
      smart00147
      Location:622890
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:208317
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:58184
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:348457
      RasGEF_N; RasGEF N-terminal motif
    12. XM_036159377.1XP_036015270.1  rap guanine nucleotide exchange factor 3 isoform X7

      UniProtKB/TrEMBL
      Q3UQC2
      Conserved Domains (4) summary
      smart00147
      Location:695949
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:281390
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:131257
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:421530
      RasGEF_N; RasGEF N-terminal motif
    13. XM_036159376.1XP_036015269.1  rap guanine nucleotide exchange factor 3 isoform X5

      UniProtKB/TrEMBL
      Q3UQC2
      Conserved Domains (4) summary
      smart00147
      Location:695952
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:281390
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:131257
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:421530
      RasGEF_N; RasGEF N-terminal motif
    14. XM_036159374.1XP_036015267.1  rap guanine nucleotide exchange factor 3 isoform X1

      UniProtKB/TrEMBL
      Q3UQC2
      Conserved Domains (4) summary
      smart00147
      Location:695963
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:281390
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:131257
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:421530
      RasGEF_N; RasGEF N-terminal motif
    15. XM_017316584.3XP_017172073.1  rap guanine nucleotide exchange factor 3 isoform X6

      UniProtKB/TrEMBL
      Q3UQC2
      Conserved Domains (4) summary
      smart00147
      Location:692949
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:278387
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:131254
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:418527
      RasGEF_N; RasGEF N-terminal motif
    16. XM_017316582.3XP_017172071.1  rap guanine nucleotide exchange factor 3 isoform X3

      UniProtKB/TrEMBL
      Q3UQC2
      Conserved Domains (4) summary
      smart00147
      Location:692960
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:278387
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:131254
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:418527
      RasGEF_N; RasGEF N-terminal motif
    17. XM_011245603.1XP_011243905.1  rap guanine nucleotide exchange factor 3 isoform X16

      Conserved Domains (2) summary
      smart00147
      Location:233501
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cl02520
      Location:185
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    18. XM_036159383.1XP_036015276.1  rap guanine nucleotide exchange factor 3 isoform X15

      Conserved Domains (2) summary
      cd06224
      Location:4125
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:273541
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

    RNA

    1. XR_004938829.1 RNA Sequence

    2. XR_001781519.3 RNA Sequence

    3. XR_004938830.1 RNA Sequence

    4. XR_004938831.1 RNA Sequence

    5. XR_004938832.1 RNA Sequence