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    Abcc2 ATP-binding cassette, sub-family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 12780, updated on 9-Dec-2024

    Summary

    Official Symbol
    Abcc2provided by MGI
    Official Full Name
    ATP-binding cassette, sub-family member 2provided by MGI
    Primary source
    MGI:MGI:1352447
    See related
    Ensembl:ENSMUSG00000025194 AllianceGenome:MGI:1352447
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mrp2; cMRP; Abc30; Cmoat
    Summary
    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the canalicular surface of the hepatocyte and in biliary transport, and appears to contribute to drug resistance in mammalian cells. Several different mutations in the human gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. Alternative splice variants have been observed for this gene; however, they have not been fully described. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in liver adult (RPKM 39.0), kidney adult (RPKM 24.8) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Abcc2 in Genome Data Viewer
    Location:
    19 C3; 19 36.67 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (43770747..43826771)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (43782308..43838332)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ectonucleoside triphosphate diphosphohydrolase 7 Neighboring gene STARR-positive B cell enhancer ABC_E11677 Neighboring gene cytochrome c oxidase assembly protein 15 Neighboring gene STARR-positive B cell enhancer ABC_E5703 Neighboring gene cutC copper transporter Neighboring gene STARR-seq mESC enhancer starr_46204 Neighboring gene predicted gene 10768 Neighboring gene dynamin binding protein Neighboring gene predicted gene, 24400

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type glutathione S-conjugate transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ABC-type glutathione S-conjugate transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ABC-type xenobiotic transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ABC-type xenobiotic transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATPase-coupled transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables bilirubin transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables bilirubin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in antibiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in benzylpenicillin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bile acid and bile salt transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bile acid and bile salt transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in bilirubin transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bilirubin transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in canalicular bile acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detoxification of mercury ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular chloride ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukotriene transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in leukotriene transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mercury ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in organic anion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prostaglandin transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to estrogen ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in thyroid hormone transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transepithelial transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic export from cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in xenobiotic export from cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in xenobiotic transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic transport across blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercellular canaliculus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular canaliculus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ATP-binding cassette sub-family C member 2
    Names
    ATP-binding cassette, sub-family C (CFTR/MRP), member 2
    canalicular multispecific organic anion transporter 1
    multidrug resistance protein 2
    multidrug resistance-associated protein 2
    NP_038834.2
    XP_006526688.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013806.2NP_038834.2  ATP-binding cassette sub-family C member 2

      See identical proteins and their annotated locations for NP_038834.2

      Status: VALIDATED

      Source sequence(s)
      AC132251, AC141888, AF282773
      Consensus CDS
      CCDS29838.1
      UniProtKB/Swiss-Prot
      Q8VI46, Q8VI47
      UniProtKB/TrEMBL
      Q9JIH8
      Related
      ENSMUSP00000026208.5, ENSMUST00000026208.6
      Conserved Domains (1) summary
      TIGR00957
      Location:101535
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      43770747..43826771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526625.4XP_006526688.1  ATP-binding cassette sub-family C member 2 isoform X1

      UniProtKB/TrEMBL
      Q9JIH8
      Conserved Domains (1) summary
      TIGR00957
      Location:171487
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)