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    Scd3 stearoyl-coenzyme A desaturase 3 [ Mus musculus (house mouse) ]

    Gene ID: 30049, updated on 9-Dec-2024

    Summary

    Official Symbol
    Scd3provided by MGI
    Official Full Name
    stearoyl-coenzyme A desaturase 3provided by MGI
    Primary source
    MGI:MGI:1353437
    See related
    Ensembl:ENSMUSG00000025202 AllianceGenome:MGI:1353437
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930513N16Rik
    Summary
    Enables palmitoyl-CoA 9-desaturase activity. Acts upstream of or within monounsaturated fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum; membrane; and nucleolus. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and skeleton. Orthologous to human SCD (stearoyl-CoA desaturase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 90.3), mammary gland adult (RPKM 75.0) and 6 other tissues See more
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    Genomic context

    See Scd3 in Genome Data Viewer
    Location:
    19 C3; 19 37.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (44191727..44232455)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44203288..44244016)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene CWF19 like cell cycle control factor 1 Neighboring gene predicted gene, 52383 Neighboring gene STARR-seq mESC enhancer starr_46220 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 2 Neighboring gene polycystic kidney disease 2-like 1 Neighboring gene STARR-seq mESC enhancer starr_46221 Neighboring gene STARR-seq mESC enhancer starr_46222 Neighboring gene STARR-positive B cell enhancer mm9_chr19:44341455-44341756 Neighboring gene stearoyl-coenzyme A desaturase pseudogene Neighboring gene predicted gene, 54046 Neighboring gene predicted gene, 35183

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables iron ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables palmitoyl-CoA 9-desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables palmitoyl-CoA 9-desaturase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables palmitoyl-CoA 9-desaturase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    NOT enables stearoyl-CoA 9-desaturase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables stearoyl-CoA 9-desaturase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables stearoyl-CoA 9-desaturase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    acyl-CoA desaturase 3
    Names
    delta(9)-desaturase 3
    fatty acid desaturase 3
    palmitoyl-CoA desaturase
    stearoyl-CoA desaturase 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024450.2NP_077770.1  acyl-CoA desaturase 3

      See identical proteins and their annotated locations for NP_077770.1

      Status: VALIDATED

      Source sequence(s)
      AC123853, AC125101, AF272037
      Consensus CDS
      CCDS29847.1
      UniProtKB/Swiss-Prot
      Q3UWK5, Q99PL7, Q9D550
      UniProtKB/TrEMBL
      Q8BNZ5
      Related
      ENSMUSP00000026220.6, ENSMUST00000026220.7
      Conserved Domains (2) summary
      cd03505
      Location:97337
      Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
      pfam00487
      Location:102306
      FA_desaturase; Fatty acid desaturase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      44191727..44232455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)