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    Cox15 cytochrome c oxidase assembly protein 15 [ Mus musculus (house mouse) ]

    Gene ID: 226139, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cox15provided by MGI
    Official Full Name
    cytochrome c oxidase assembly protein 15provided by MGI
    Primary source
    MGI:MGI:1920112
    See related
    Ensembl:ENSMUSG00000040018 AllianceGenome:MGI:1920112
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HAS; 2900026G05Rik
    Summary
    Predicted to enable oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor and oxidoreductase activity, acting on the CH-CH group of donors. Predicted to be involved in cytochrome complex assembly and heme A biosynthetic process. Located in mitochondrial inner membrane. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; and mitochondrial complex IV deficiency nuclear type 6. Orthologous to human COX15 (cytochrome c oxidase assembly homolog COX15). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 15.9), large intestine adult (RPKM 13.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Cox15 in Genome Data Viewer
    Location:
    19 C3; 19 36.67 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (43721693..43741439, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (43733254..43753000, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25, member 28 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:43749453-43749636 Neighboring gene cDNA sequence BC037704 Neighboring gene STARR-positive B cell enhancer ABC_E7661 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 7 Neighboring gene STARR-positive B cell enhancer ABC_E11677 Neighboring gene STARR-positive B cell enhancer ABC_E5703 Neighboring gene cutC copper transporter Neighboring gene ATP-binding cassette, sub-family member 2 Neighboring gene STARR-seq mESC enhancer starr_46204

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC18952

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cytochrome complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytochrome complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heme A biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of cytochrome complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of cytochrome complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    heme A synthase COX15
    Names
    COX15 homolog, cytochrome c oxidase assembly protein
    cytochrome c oxidase assembly protein COX15 homolog
    NP_659123.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144874.4NP_659123.2  heme A synthase COX15

      See identical proteins and their annotated locations for NP_659123.2

      Status: VALIDATED

      Source sequence(s)
      AC141888, AK048099, AK051792
      Consensus CDS
      CCDS29836.1
      UniProtKB/Swiss-Prot
      Q3URB2, Q8BJ03, Q8VDN0, Q921K5
      Related
      ENSMUSP00000041820.6, ENSMUST00000045562.6
      Conserved Domains (1) summary
      cl19388
      Location:69410
      COX15-CtaA; Cytochrome oxidase assembly protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      43721693..43741439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)