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    Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 [ Mus musculus (house mouse) ]

    Gene ID: 226143, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cyp2c23provided by MGI
    Official Full Name
    cytochrome P450, family 2, subfamily c, polypeptide 23provided by MGI
    Primary source
    MGI:MGI:1888897
    See related
    Ensembl:ENSMUSG00000025197 AllianceGenome:MGI:1888897
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cyp2c44; b2b386Clo
    Summary
    Predicted to enable arachidonate epoxygenase activity; heme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in epoxygenase P450 pathway; icosanoid biosynthetic process; and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in metanephros; stomach; submandibular gland; and testis. Orthologous to human CYP2C23P (cytochrome P450 family 2 subfamily C member 23, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 77.1), liver E18 (RPKM 26.8) and 3 other tissues See more
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    Genomic context

    See Cyp2c23 in Genome Data Viewer
    Location:
    19 C3; 19 36.69 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (43993461..44017695, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44005022..44029256, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene dynamin binding protein Neighboring gene RIKEN cDNA 4933403J19 gene Neighboring gene carboxypeptidase N, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_46217 Neighboring gene ER lipid raft associated 1 Neighboring gene uracil DNA glycosylase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11678 Neighboring gene conserved helix-loop-helix ubiquitous kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC25860, MGC37835, MGC37849

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epoxygenase P450 pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in icosanoid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in organic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cytochrome P450 2C44
    Names
    Mutant line 386
    arachidonic acid epoxygenase
    cytochrome P450, 2c44
    cytochrome P450, family 2, subfamily c, polypeptide 44
    NP_001001446.3
    NP_001161377.1
    XP_017173651.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001446.3NP_001001446.3  cytochrome P450 2C44 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC124693, AK149451
      Consensus CDS
      CCDS29841.1
      UniProtKB/Swiss-Prot
      E9Q5K4, Q6IEF7, Q8BWN7, Q8QZW4
      UniProtKB/TrEMBL
      Q8CIE7
      Related
      ENSMUSP00000026211.9, ENSMUST00000026211.10
      Conserved Domains (1) summary
      cd20665
      Location:65489
      CYP2C-like; cytochrome P450 family 2, subfamily C, and similar cytochrome P450s
    2. NM_001167905.1NP_001161377.1  cytochrome P450 2C44 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC124693, AK050436
      Consensus CDS
      CCDS84445.1
      UniProtKB/TrEMBL
      Q3UEM4
      Related
      ENSMUSP00000148377.2, ENSMUST00000211830.2
      Conserved Domains (1) summary
      pfam00067
      Location:34445
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      43993461..44017695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318162.1XP_017173651.1  cytochrome P450 2C44 isoform X1

      UniProtKB/TrEMBL
      Q8CIE7
      Conserved Domains (1) summary
      pfam00067
      Location:34496
      p450; Cytochrome P450