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    Dnajc1 DnaJ heat shock protein family (Hsp40) member C1 [ Mus musculus (house mouse) ]

    Gene ID: 13418, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dnajc1provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C1provided by MGI
    Primary source
    MGI:MGI:103268
    See related
    Ensembl:ENSMUSG00000026740 AllianceGenome:MGI:103268
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MTJ1; ERdj1; ERj1p; Dnajl1; 4733401K02Rik; D230036H06Rik
    Summary
    Enables protein-folding chaperone binding activity. Acts upstream of or within protein folding and regulation of translation. Located in endoplasmic reticulum and plasma membrane. Orthologous to human DNAJC1 (DnaJ heat shock protein family (Hsp40) member C1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 10.4), thymus adult (RPKM 9.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dnajc1 in Genome Data Viewer
    Location:
    2 A3; 2 12.89 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (18210445..18402025, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (18205634..18394099, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 Neighboring gene predicted gene, 25147 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene GAR1 ribonucleoprotein homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_03801 Neighboring gene STARR-seq mESC enhancer starr_03802 Neighboring gene STARR-positive B cell enhancer ABC_E11123 Neighboring gene STARR-seq mESC enhancer starr_03803 Neighboring gene STARR-seq mESC enhancer starr_03805 Neighboring gene STARR-seq mESC enhancer starr_03806 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:18424168-18424351 Neighboring gene STARR-seq mESC enhancer starr_03808 Neighboring gene STARR-seq mESC enhancer starr_03809 Neighboring gene STARR-seq mESC enhancer starr_03810 Neighboring gene STARR-positive B cell enhancer ABC_E11124 Neighboring gene nuclear encoded tRNA asparagine 9 (anticodon GTT) Neighboring gene STARR-seq mESC enhancer starr_03811 Neighboring gene aminoadipate-semialdehyde dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-folding chaperone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribosome binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein folding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dnaJ homolog subfamily C member 1
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 1
    DnaJ-like protein 1
    dnaJ protein homolog MTJ1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190817.2NP_001177746.1  dnaJ homolog subfamily C member 1 precursor

      See identical proteins and their annotated locations for NP_001177746.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL845265, AL928557, AL928620
      Consensus CDS
      CCDS15709.1
      UniProtKB/Swiss-Prot
      Q61712
      Related
      ENSMUSP00000088980.6, ENSMUST00000091418.12
      Conserved Domains (3) summary
      smart00717
      Location:493542
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:494541
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00226
      Location:61122
      DnaJ; DnaJ domain
    2. NM_007869.4NP_031895.1  dnaJ homolog subfamily C member 1 precursor

      See identical proteins and their annotated locations for NP_031895.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL845265, AL928557, AL928620
      Consensus CDS
      CCDS15709.1
      UniProtKB/Swiss-Prot
      Q61712
      Related
      ENSMUSP00000126321.2, ENSMUST00000166495.8
      Conserved Domains (3) summary
      smart00717
      Location:493542
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:494541
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00226
      Location:61122
      DnaJ; DnaJ domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      18210445..18402025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238947.3XP_011237249.1  dnaJ homolog subfamily C member 1 isoform X1

      Conserved Domains (2) summary
      cd00167
      Location:244291
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      cl30717
      Location:103243
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

    RNA

    1. XR_865923.4 RNA Sequence