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    Ndst4 N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4 [ Mus musculus (house mouse) ]

    Gene ID: 64580, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ndst4provided by MGI
    Official Full Name
    N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4provided by MGI
    Primary source
    MGI:MGI:1932545
    See related
    Ensembl:ENSMUSG00000027971 AllianceGenome:MGI:1932545
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930439H17Rik
    Summary
    Enables N-acetylglucosamine deacetylase activity and [heparan sulfate]-glucosamine N-sulfotransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including genitourinary system; liver; lung; nervous system; and spleen. Orthologous to human NDST4 (N-deacetylase and N-sulfotransferase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 2.2), testis adult (RPKM 1.9) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ndst4 in Genome Data Viewer
    Location:
    3 G1; 3 54.68 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (125197678..125522550)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (125404029..125728351)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08921 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 35237 Neighboring gene STARR-seq mESC enhancer starr_08922 Neighboring gene predicted gene, 35186 Neighboring gene STARR-seq mESC enhancer starr_08923 Neighboring gene predicted gene, 40145 Neighboring gene UDP galactosyltransferase 8A Neighboring gene STARR-seq mESC enhancer starr_08924 Neighboring gene STARR-seq mESC enhancer starr_08925 Neighboring gene STARR-seq mESC enhancer starr_08928 Neighboring gene predicted gene, 40146

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Alteration of colonic epithelial cell differentiation in mice deficient for glucosaminyl N-deacetylase/N-sulfotransferase 4. Jao TM, et al. Oncotarget, 2016 Dec 20. PMID 27793051, Free PMC Article
    2. Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin. Dagälv A, et al. J Biol Chem, 2011 Dec 30. PMID 22049073, Free PMC Article
    3. Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites. Grobe K, et al. J Biol Chem, 2002 Aug 23. PMID 12070138
    4. FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing β-catenin signaling. Liu C, et al. Development, 2013 Nov. PMID 24067353, Free PMC Article
    5. Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4. Aikawa J, et al. J Biol Chem, 2001 Feb 23. PMID 11087757

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this study revealed the involvement of Ndst4 in the development and homeostasis of colonic epithelium
      Title: Alteration of colonic epithelial cell differentiation in mice deficient for glucosaminyl N-deacetylase/N-sulfotransferase 4.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetylglucosamine deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables [heparan sulfate]-glucosamine N-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [heparan sulfate]-glucosamine N-sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heparin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4
    Names
    N-HSST 4
    N-deacetylase/N-sulfotransferase 4
    N-heparan sulfate sulfotransferase 4
    NDST-4
    glucosaminyl N-deacetylase/N-sulfotransferase 4
    NP_072087.2
    XP_006501922.1
    XP_006501923.1
    XP_011238491.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022565.3 → NP_072087.2  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4

      See identical proteins and their annotated locations for NP_072087.2

      Status: VALIDATED

      Source sequence(s)
      AC111141, AC140797, AC164153
      Consensus CDS
      CCDS17820.1
      UniProtKB/Swiss-Prot
      D3Z1R7, Q9EQW8
      Related
      ENSMUSP00000133341.3, ENSMUST00000173932.8
      Conserved Domains (2) summary
      pfam00685
      Location:594 → 845
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:20 → 505
      HSNSD; heparan sulfate-N-deacetylase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      125197678..125522550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501859.2 → XP_006501922.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 isoform X1

      Conserved Domains (1) summary
      pfam12062
      Location:21 → 505
      HSNSD; heparan sulfate-N-deacetylase

    2. XM_011240189.2 → XP_011238491.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 isoform X2

      Conserved Domains (1) summary
      pfam12062
      Location:21 → 505
      HSNSD; heparan sulfate-N-deacetylase

    3. XM_006501860.2 → XP_006501923.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 isoform X3

      Conserved Domains (2) summary
      pfam00685
      Location:215 → 466
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:1 → 126
      HSNSD; heparan sulfate-N-deacetylase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQW8.2 GenPept UniProtKB/Swiss-Prot:Q9EQW8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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