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    Fip1l1 factor interacting with PAPOLA and CPSF1 [ Mus musculus (house mouse) ]

    Gene ID: 66899, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fip1l1provided by MGI
    Official Full Name
    factor interacting with PAPOLA and CPSF1provided by MGI
    Primary source
    MGI:MGI:1914149
    See related
    Ensembl:ENSMUSG00000029227 AllianceGenome:MGI:1914149
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rje; 1300019H17Rik
    Summary
    Predicted to enable enzyme regulator activity. Predicted to be involved in mRNA processing. Predicted to act upstream of or within regulation of mRNA 3'-end processing. Located in nucleus. Part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human FIP1L1 (factor interacting with PAPOLA and CPSF1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 15.0), CNS E14 (RPKM 12.7) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fip1l1 in Genome Data Viewer
    Location:
    5 C3.3; 5 39.51 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (74695774..74759451)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (74535438..74598790)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:74596657-74596859 Neighboring gene RAS-like, family 11, member B Neighboring gene Sec1 family domain containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:74656347-74656530 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:74656616-74656725 Neighboring gene STARR-seq mESC enhancer starr_13406 Neighboring gene predicted gene, 32064 Neighboring gene VISTA enhancer mm139 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:74762842-74763025 Neighboring gene STARR-seq mESC enhancer starr_13407 Neighboring gene STARR-positive B cell enhancer ABC_E2746 Neighboring gene STARR-positive B cell enhancer ABC_E6339 Neighboring gene ligand of numb-protein X 1 Neighboring gene STARR-seq mESC enhancer starr_13408 Neighboring gene predicted gene, 32304 Neighboring gene STARR-seq mESC enhancer starr_13409 Neighboring gene predicted gene 15984

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    pre-mRNA 3'-end-processing factor FIP1
    Names
    FIP1 like 1
    FIP1-like 1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159573.2NP_001153045.1  pre-mRNA 3'-end-processing factor FIP1 isoform 1

      See identical proteins and their annotated locations for NP_001153045.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC113300, AC164523
      Consensus CDS
      CCDS51520.1
      UniProtKB/Swiss-Prot
      Q8BWX7, Q99LH0, Q9D824, Q9DBB2
      Related
      ENSMUSP00000109164.2, ENSMUST00000113536.8
      Conserved Domains (1) summary
      pfam05182
      Location:153195
      Fip1; Fip1 motif
    2. NM_001159574.2NP_001153046.1  pre-mRNA 3'-end-processing factor FIP1 isoform 3

      See identical proteins and their annotated locations for NP_001153046.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC113300, AC164523
      Consensus CDS
      CCDS51521.1
      UniProtKB/Swiss-Prot
      Q9D824
      Related
      ENSMUSP00000109163.3, ENSMUST00000113535.9
      Conserved Domains (1) summary
      pfam05182
      Location:153195
      Fip1; Fip1 motif
    3. NM_001376964.1NP_001363893.1  pre-mRNA 3'-end-processing factor FIP1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC113300, AC164523
      Conserved Domains (1) summary
      pfam05182
      Location:153195
      Fip1; Fip1 motif
    4. NM_001376965.1NP_001363894.1  pre-mRNA 3'-end-processing factor FIP1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC113300, AC164523
      Conserved Domains (1) summary
      pfam05182
      Location:153195
      Fip1; Fip1 motif
    5. NM_024183.6NP_077145.2  pre-mRNA 3'-end-processing factor FIP1 isoform 2

      See identical proteins and their annotated locations for NP_077145.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC113300, AC164523
      Consensus CDS
      CCDS19346.1
      UniProtKB/Swiss-Prot
      Q9D824
      Related
      ENSMUSP00000079059.6, ENSMUST00000080164.12
      Conserved Domains (1) summary
      pfam05182
      Location:153195
      Fip1; Fip1 motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      74695774..74759451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504265.5XP_006504328.1  pre-mRNA 3'-end-processing factor FIP1 isoform X1

      See identical proteins and their annotated locations for XP_006504328.1

      Related
      ENSMUSP00000109162.3, ENSMUST00000113534.9
      Conserved Domains (1) summary
      pfam05182
      Location:153195
      Fip1; Fip1 motif
    2. XM_006504267.5XP_006504330.1  pre-mRNA 3'-end-processing factor FIP1 isoform X3

      Conserved Domains (1) summary
      pfam05182
      Location:153195
      Fip1; Fip1 motif
    3. XM_030254768.2XP_030110628.1  pre-mRNA 3'-end-processing factor FIP1 isoform X2

      Conserved Domains (1) summary
      pfam05182
      Location:153195
      Fip1; Fip1 motif
    4. XM_036165429.1XP_036021322.1  pre-mRNA 3'-end-processing factor FIP1 isoform X5

      Conserved Domains (1) summary
      pfam05182
      Location:153195
      Fip1; Fip1 motif
    5. XM_036165428.1XP_036021321.1  pre-mRNA 3'-end-processing factor FIP1 isoform X4

      Conserved Domains (1) summary
      pfam05182
      Location:153195
      Fip1; Fip1 motif
    6. XM_036165431.1XP_036021324.1  pre-mRNA 3'-end-processing factor FIP1 isoform X7

      Conserved Domains (1) summary
      pfam05182
      Location:153195
      Fip1; Fip1 motif
    7. XM_036165430.1XP_036021323.1  pre-mRNA 3'-end-processing factor FIP1 isoform X6

      Conserved Domains (1) summary
      pfam05182
      Location:153195
      Fip1; Fip1 motif