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    Trrap transformation/transcription domain-associated protein [ Mus musculus (house mouse) ]

    Gene ID: 100683, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trrapprovided by MGI
    Official Full Name
    transformation/transcription domain-associated proteinprovided by MGI
    Primary source
    MGI:MGI:2153272
    See related
    Ensembl:ENSMUSG00000045482 AllianceGenome:MGI:2153272
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables transcription coactivator activity. Acts upstream of or within regulation of DNA-templated transcription. Part of SAGA complex and transcription regulator complex. Is expressed in several structures, including cerebral cortex; cranial ganglion; submandibular gland primordium; tooth; and vibrissa. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 75. Orthologous to human TRRAP (transformation/transcription domain associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 24.1), thymus adult (RPKM 17.5) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Trrap in Genome Data Viewer
    Location:
    5 G2; 5 84.77 cM
    Exon count:
    75
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (144704547..144796588)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (144767737..144859778)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 130 Neighboring gene STARR-seq mESC enhancer starr_14819 Neighboring gene predicted gene, 38739 Neighboring gene predicted gene, 23995 Neighboring gene SMAD specific E3 ubiquitin protein ligase 1 Neighboring gene microRNA 7039 Neighboring gene predicted gene, 33821

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of NuA4 histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SAGA complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SAGA complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of Swr1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Swr1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of histone acetyltransferase complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFTC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFTC complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transformation/transcription domain-associated protein
    Names
    tra1 homolog
    transactivation/transformation-domain associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081362.2NP_001074831.1  transformation/transcription domain-associated protein

      Status: VALIDATED

      Source sequence(s)
      AC113295, AC131728
      Consensus CDS
      CCDS39379.1
      UniProtKB/TrEMBL
      E9PZA7, E9QLK7
      Related
      ENSMUSP00000098035.4, ENSMUST00000100467.10
      Conserved Domains (3) summary
      COG5032
      Location:25263847
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:34843771
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28423174
      FAT; FAT domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      144704547..144796588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504782.3XP_006504845.1  transformation/transcription domain-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006504845.1

      UniProtKB/TrEMBL
      A0A1D5RLL4
      Conserved Domains (3) summary
      COG5032
      Location:25523911
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:35223835
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28683211
      FAT; FAT domain
    2. XM_030254015.1XP_030109875.1  transformation/transcription domain-associated protein isoform X3

      UniProtKB/TrEMBL
      E9PWT1
      Conserved Domains (3) summary
      COG5032
      Location:25513910
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:35213834
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28673210
      FAT; FAT domain
    3. XM_006504781.3XP_006504844.1  transformation/transcription domain-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006504844.1

      UniProtKB/TrEMBL
      A0A1D5RLL4
      Conserved Domains (3) summary
      COG5032
      Location:25523911
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:35223835
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28683211
      FAT; FAT domain
    4. XM_006504789.3XP_006504852.1  transformation/transcription domain-associated protein isoform X10

      UniProtKB/TrEMBL
      A0A1D5RLL4
      Conserved Domains (3) summary
      COG5032
      Location:25523885
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:35223809
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28683211
      FAT; FAT domain
    5. XM_006504787.3XP_006504850.1  transformation/transcription domain-associated protein isoform X7

      UniProtKB/TrEMBL
      A0A1D5RLL4
      Conserved Domains (3) summary
      COG5032
      Location:25523893
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:35043817
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28683211
      FAT; FAT domain
    6. XM_006504784.3XP_006504847.1  transformation/transcription domain-associated protein isoform X2

      UniProtKB/TrEMBL
      A0A1D5RLL4
      Conserved Domains (3) summary
      COG5032
      Location:25523910
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:35213834
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28683211
      FAT; FAT domain
    7. XM_006504790.3XP_006504853.1  transformation/transcription domain-associated protein isoform X11

      UniProtKB/TrEMBL
      A0A1D5RLL4
      Conserved Domains (2) summary
      COG5032
      Location:25523884
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:35213808
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    8. XM_030254018.1XP_030109878.1  transformation/transcription domain-associated protein isoform X8

      UniProtKB/TrEMBL
      A0A1D5RLL4
      Conserved Domains (3) summary
      COG5032
      Location:25523892
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:35033816
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28683211
      FAT; FAT domain
    9. XM_006504793.3XP_006504856.1  transformation/transcription domain-associated protein isoform X15

      UniProtKB/TrEMBL
      A0A1D5RLL4
      Related
      ENSMUSP00000148419.2, ENSMUST00000213013.2
      Conserved Domains (2) summary
      COG5032
      Location:25523866
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:35033790
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    10. XM_006504786.3XP_006504849.1  transformation/transcription domain-associated protein isoform X4

      UniProtKB/TrEMBL
      A0A1D5RLL4
      Conserved Domains (3) summary
      COG5032
      Location:25523900
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:35113824
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28683200
      FAT; FAT domain
    11. XM_017320576.2XP_017176065.1  transformation/transcription domain-associated protein isoform X13

      UniProtKB/TrEMBL
      A0A1D5RLL4
      Conserved Domains (3) summary
      COG5032
      Location:25523874
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:35113798
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28683200
      FAT; FAT domain
    12. XM_017320575.2XP_017176064.1  transformation/transcription domain-associated protein isoform X5

      UniProtKB/TrEMBL
      A0A1D5RLL4
      Conserved Domains (3) summary
      COG5032
      Location:25523899
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:35103823
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28683200
      FAT; FAT domain
    13. XM_036164690.1XP_036020583.1  transformation/transcription domain-associated protein isoform X12

      UniProtKB/TrEMBL
      A0A1D5RLL4
      Conserved Domains (3) summary
      COG5032
      Location:25523881
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:34923805
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28583200
      FAT; FAT domain
    14. XM_017320577.2XP_017176066.1  transformation/transcription domain-associated protein isoform X16

      UniProtKB/TrEMBL
      A0A1D5RLL4
      Conserved Domains (3) summary
      COG5032
      Location:25523855
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:34923779
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28683200
      FAT; FAT domain
    15. XM_011240999.3XP_011239301.1  transformation/transcription domain-associated protein isoform X6

      UniProtKB/TrEMBL
      A0A1D5RLL4
      Conserved Domains (3) summary
      COG5032
      Location:25343893
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:35043817
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28503193
      FAT; FAT domain
    16. XM_006504788.3XP_006504851.1  transformation/transcription domain-associated protein isoform X9

      UniProtKB/TrEMBL
      E9PZA7
      Conserved Domains (3) summary
      COG5032
      Location:25273886
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:34973810
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28433186
      FAT; FAT domain
    17. XM_006504795.3XP_006504858.1  transformation/transcription domain-associated protein isoform X19

      UniProtKB/TrEMBL
      E9PZA7
      Conserved Domains (3) summary
      COG5032
      Location:25273830
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:34673754
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28433175
      FAT; FAT domain
    18. XM_006504785.3XP_006504848.1  transformation/transcription domain-associated protein isoform X3

      UniProtKB/TrEMBL
      E9PWT1
      Conserved Domains (3) summary
      COG5032
      Location:25513910
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:35213834
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28673210
      FAT; FAT domain
    19. XM_006504792.4XP_006504855.1  transformation/transcription domain-associated protein isoform X14

      UniProtKB/TrEMBL
      A0A1D5RLL4
      Related
      ENSMUSP00000122021.2, ENSMUST00000132925.2
      Conserved Domains (3) summary
      COG5032
      Location:25523873
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:35103797
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28683200
      FAT; FAT domain
    20. XM_006504794.4XP_006504857.1  transformation/transcription domain-associated protein isoform X17

      UniProtKB/TrEMBL
      E9PZA7
      Conserved Domains (3) summary
      COG5032
      Location:25273848
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:34853772
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28433175
      FAT; FAT domain
    21. XM_017320578.3XP_017176067.1  transformation/transcription domain-associated protein isoform X18

      UniProtKB/TrEMBL
      E9PZA7, E9QLK7
      Conserved Domains (3) summary
      COG5032
      Location:25263847
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:34843771
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28423174
      FAT; FAT domain
    22. XM_006504783.4XP_006504846.1  transformation/transcription domain-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006504846.1

      UniProtKB/TrEMBL
      A0A1D5RLL4
      Conserved Domains (3) summary
      COG5032
      Location:25523911
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:35223835
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28683211
      FAT; FAT domain
    23. XM_030254016.1XP_030109876.1  transformation/transcription domain-associated protein isoform X3

      UniProtKB/TrEMBL
      E9PWT1
      Conserved Domains (3) summary
      COG5032
      Location:25513910
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:35213834
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:28673210
      FAT; FAT domain

    RNA

    1. XR_377190.4 RNA Sequence

    2. XR_377189.4 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_133901.2: Suppressed sequence

      Description
      NM_133901.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.