Fzd1 frizzled class receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fzd1provided by MGI
Official Full Name: frizzled class receptor 1provided by MGI
Primary source: MGI:MGI:1196625
See related: Ensembl:ENSMUSG00000044674 AllianceGenome:MGI:1196625
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fz1; FZ-1
Summary: Enables Wnt-protein binding activity. Involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway and regulation of presynapse assembly. Acts upstream of or within several processes, including hard palate development; heart morphogenesis; and negative regulation of signal transduction. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Orthologous to human FZD1 (frizzled class receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 5 A1; 5 2.61 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (4803839..4808216, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (4753839..4758216, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FZD1 regulates specific stages of adult hippocampal neurogenesis.
Title: Frizzled-1 receptor regulates adult hippocampal neurogenesis.
Suppressed expression of Fzd1 in myogenic cells from aged mice results in a significant increase in myogenic differentiation, and its forced expression in those from young mice results in its drastic inhibition.
Title: Critical role of Frizzled1 in age-related alterations of Wnt/β-catenin signal in myogenic cells during differentiation.
The results indicate the involvement of Wnt1 and Fzd1 in the pathogenesis and development of amyotrophic lateral sclerosis.
Title: Role of Wnt1 and Fzd1 in the spinal cord pathogenesis of amyotrophic lateral sclerosis-transgenic mice.
results indicate that frizzled homolog 1(Drosophila)(Fzd1) is required for normal female fertility and may act in part to regulate oocyte maturation and cumulus cell function
Title: FZD1 regulates cumulus expansion genes and is required for normal female fertility in mice.
Wnt/Fzd signaling is involved in balancing the inflammatory response to microbial stimulation of innate immune cells of vertebrate origin
Title: Frizzled1 is a marker of inflammatory macrophages, and its ligand Wnt3a is involved in reprogramming Mycobacterium tuberculosis-infected macrophages.
Frizzled signaling is involved in diverse tissue closure processes, defects in which account for some of the most common congenital anomalies.
Title: Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes.
Indicate that myofibroblast migration and differentiation are modulated via Wnt/Fzd signalling.
Title: Wnt/frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts.
Fzd1 transcription increased during pulmonary fibrosis in mice.
Title: Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.
Fz-1 is expressed at distinct stages of follicular development.
Title: Regulated expression of Wnts and Frizzleds at specific stages of follicular development in the rodent ovary.
Data demonstrate that Wnt7b signals through Fzd1 and -10 and LRP5 and implicate these Wnt coreceptors in the regulation of lung airway and vascular development.
Title: Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fzd2 (e-PCR), detects polymorphism
- UniSTS:532232

Fzd1 (e-PCR), detects polymorphism
- UniSTS:506907

REN110715 (e-PCR)
- UniSTS:435511

Fzd1 (e-PCR), detects polymorphism
- UniSTS:495987

Fzd1 (e-PCR), detects polymorphism
- UniSTS:516473

Fzd1 (e-PCR), detects polymorphism
- UniSTS:228511

AW227548 (e-PCR)
- UniSTS:179129

Fzd1 (e-PCR), detects polymorphism
- UniSTS:508381

Fzd1 (e-PCR), detects polymorphism
- UniSTS:508382

NoName (e-PCR)
- UniSTS:548577

Fzd1 (e-PCR), detects polymorphism
- UniSTS:547565

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt receptor activity	ISO Inferred from Sequence Orthology more info
enables Wnt receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables Wnt-protein binding	ISO Inferred from Sequence Orthology more info
enables frizzled binding	IEA Inferred from Electronic Annotation more info
enables frizzled binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in astrocyte-dopaminergic neuron signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autocrine signaling	IEA Inferred from Electronic Annotation more info
involved_in autocrine signaling	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endothelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within endothelial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hard palate development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within membranous septum morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within muscular septum morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within outflow tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mesenchymal stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of mesenchymal stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular septum morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: frizzled-1

Names: frizzled homolog 1; mFz1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021457.3 → NP_067432.2 frizzled-1 precursor

See identical proteins and their annotated locations for NP_067432.2

Status: VALIDATED

Source sequence(s)

AK143101, BC053010, BE948559

Consensus CDS

CCDS19072.1

UniProtKB/Swiss-Prot

O08974, O70421, Q7TS82

Related

ENSMUSP00000058629.5, ENSMUST00000054294.7

Conserved Domains (2) summary

cd07465
Location:107 → 233

CRD_FZ1; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 1 (Fz1) receptor

cd15247
Location:294 → 641

7tmF_FZD1; class F mammalian frizzled subfamily 1, member of 7-transmembrane G protein-coupled receptors