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    Ttc12 tetratricopeptide repeat domain 12 [ Mus musculus (house mouse) ]

    Gene ID: 235330, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ttc12provided by MGI
    Official Full Name
    tetratricopeptide repeat domain 12provided by MGI
    Primary source
    MGI:MGI:2444588
    See related
    Ensembl:ENSMUSG00000040219 AllianceGenome:MGI:2444588
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E330017O07Rik
    Summary
    Predicted to be involved in axonemal dynein complex assembly and sperm axoneme assembly. Predicted to be active in centrosome and cytoplasm. Is expressed in brain ventricle and brain ventricular layer. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; alcohol dependence; drug dependence (multiple); nicotine dependence; and primary ciliary dyskinesia 45. Orthologous to human TTC12 (tetratricopeptide repeat domain 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 10.4), heart adult (RPKM 3.7) and 12 other tissues See more
    Orthologs
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    Genomic context

    See Ttc12 in Genome Data Viewer
    Location:
    9 A5.3; 9 26.83 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (49348261..49397572, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (49436961..49486275, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene dopamine receptor D2 Neighboring gene predicted gene, 46111 Neighboring gene ankyrin repeat and kinase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_24092 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:49297299-49297500 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:49297697-49297806 Neighboring gene neural cell adhesion molecule 1 Neighboring gene predicted gene 11149 Neighboring gene STARR-seq mESC enhancer starr_24096 Neighboring gene STARR-seq mESC enhancer starr_24097 Neighboring gene predicted gene, 25633

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in axonemal dynein complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in axonemal dynein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axonemal dynein complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sperm axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sperm axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sperm axoneme assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    tetratricopeptide repeat protein 12
    Names
    TPR repeat protein 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172770.3NP_766358.1  tetratricopeptide repeat protein 12

      See identical proteins and their annotated locations for NP_766358.1

      Status: PROVISIONAL

      Source sequence(s)
      AC117630, AC167980
      Consensus CDS
      CCDS23163.1
      UniProtKB/Swiss-Prot
      Q8BW49
      Related
      ENSMUSP00000056378.5, ENSMUST00000055096.5
      Conserved Domains (2) summary
      PLN03088
      Location:104254
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:105133
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      49348261..49397572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244325.2XP_030100185.1  tetratricopeptide repeat protein 12 isoform X2

      Conserved Domains (2) summary
      PLN03088
      Location:79248
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:80108
      TPR; TPR repeat [structural motif]
    2. XM_011242510.3XP_011240812.1  tetratricopeptide repeat protein 12 isoform X1

      Conserved Domains (2) summary
      TIGR00990
      Location:34175
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:105133
      TPR; TPR repeat [structural motif]
    3. XM_011242511.1XP_011240813.1  tetratricopeptide repeat protein 12 isoform X3

      Conserved Domains (2) summary
      PLN03088
      Location:104273
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:105133
      TPR; TPR repeat [structural motif]

    RNA

    1. XR_003947876.1 RNA Sequence