U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Phip pleckstrin homology domain interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 83946, updated on 9-Dec-2024

    Summary

    Official Symbol
    Phipprovided by MGI
    Official Full Name
    pleckstrin homology domain interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1932404
    See related
    Ensembl:ENSMUSG00000032253 AllianceGenome:MGI:1932404
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ndrp; Wdr11; 2810004D21Rik; 4632404O06Rik
    Summary
    Predicted to enable lysine-acetylated histone binding activity. Involved in several processes, including positive regulation of DNA-templated transcription; positive regulation of insulin-like growth factor receptor signaling pathway; and positive regulation of mitotic nuclear division. Acts upstream of or within several processes, including insulin receptor signaling pathway; positive regulation of cell population proliferation; and positive regulation of protein phosphorylation. Located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; female reproductive system; retina; and urinary system. Orthologous to human PHIP (pleckstrin homology domain interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 6.9), whole brain E14.5 (RPKM 6.8) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Phip in Genome Data Viewer
    Location:
    9 E2; 9 45.18 cM
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (82748212..82857776, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (82866159..82981668, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24780 Neighboring gene predicted gene, 35690 Neighboring gene STARR-seq mESC enhancer starr_24781 Neighboring gene STARR-positive B cell enhancer ABC_E10566 Neighboring gene interleukin-1 receptor-associated kinase 1 binding protein 1 Neighboring gene predicted gene, 38553 Neighboring gene STARR-positive B cell enhancer mm9_chr9:82782399-82782699 Neighboring gene STARR-positive B cell enhancer ABC_E10568 Neighboring gene STARR-positive B cell enhancer ABC_E10569 Neighboring gene STARR-positive B cell enhancer ABC_E11751 Neighboring gene predicted gene, 39382 Neighboring gene STARR-seq mESC enhancer starr_24784 Neighboring gene STARR-positive B cell enhancer mm9_chr9:82917229-82917530 Neighboring gene STARR-positive B cell enhancer ABC_E6779 Neighboring gene STARR-positive B cell enhancer ABC_E6780 Neighboring gene predicted gene, 39383 Neighboring gene STARR-seq mESC enhancer starr_24786 Neighboring gene predicted gene, 35746

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lysine-acetylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of insulin-like growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of type B pancreatic cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of type B pancreatic cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    PH-interacting protein
    Names
    IRS-1 PH domain-binding protein
    WD repeat domain 11
    WD repeat-containing protein 11
    neuronal differentiation-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081216.1NP_001074685.1  PH-interacting protein

      See identical proteins and their annotated locations for NP_001074685.1

      Status: VALIDATED

      Source sequence(s)
      AC121787, AC151966
      Consensus CDS
      CCDS40706.1
      UniProtKB/Swiss-Prot
      Q3TS96, Q80VI6, Q8VDD9, Q9EPY1, Q9ESL6
      UniProtKB/TrEMBL
      F8VQ93
      Related
      ENSMUSP00000034787.6, ENSMUST00000034787.12
      Conserved Domains (5) summary
      cd05496
      Location:13161434
      Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd05529
      Location:11481263
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      COG2319
      Location:178541
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:175495
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:186223
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      82748212..82857776 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511564.5XP_006511627.1  PH-interacting protein isoform X1

      UniProtKB/Swiss-Prot
      Q3TS96, Q80VI6, Q8VDD9, Q9EPY1, Q9ESL6
      Conserved Domains (4) summary
      cd05496
      Location:13151433
      Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd05529
      Location:11471262
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd00200
      Location:175495
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:186223
      7WD40; WD40 repeat [structural motif]
    2. XM_030244736.1XP_030100596.1  PH-interacting protein isoform X3

      UniProtKB/Swiss-Prot
      Q3TS96, Q80VI6, Q8VDD9, Q9EPY1, Q9ESL6
      Conserved Domains (4) summary
      cd05496
      Location:11451263
      Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd05529
      Location:9771092
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd00200
      Location:27325
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5995
      7WD40; WD40 repeat [structural motif]
    3. XM_006511565.5XP_006511628.1  PH-interacting protein isoform X2

      UniProtKB/Swiss-Prot
      Q3TS96, Q80VI6, Q8VDD9, Q9EPY1, Q9ESL6
      Conserved Domains (4) summary
      cd05496
      Location:11461264
      Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd05529
      Location:9781093
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd00200
      Location:27325
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5995
      7WD40; WD40 repeat [structural motif]
    4. XM_030244740.2XP_030100600.1  PH-interacting protein isoform X5

      Conserved Domains (2) summary
      cd05496
      Location:760878
      Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd05529
      Location:592707
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    5. XM_030244738.2XP_030100598.1  PH-interacting protein isoform X4

      Conserved Domains (2) summary
      cd05496
      Location:761879
      Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd05529
      Location:593708
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_031879.1: Suppressed sequence

      Description
      NM_031879.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.