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    Samd3 sterile alpha motif domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 268288, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Samd3provided by MGI
    Official Full Name
    sterile alpha motif domain containing 3provided by MGI
    Primary source
    MGI:MGI:2685469
    See related
    Ensembl:ENSMUSG00000051354 AllianceGenome:MGI:2685469
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm623
    Summary
    Is expressed in face; nervous system; skeleton; and tail. Orthologous to human SAMD3 (sterile alpha motif domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Samd3 in Genome Data Viewer
    Location:
    10 A4; 10 13.57 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (26105465..26148814)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (26229616..26272916)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 200A Neighboring gene predicted gene 9767 Neighboring gene high mobility group box 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26120 Neighboring gene STARR-seq mESC enhancer starr_26121 Neighboring gene L3MBTL3 histone methyl-lysine binding protein Neighboring gene STARR-seq mESC enhancer starr_26122 Neighboring gene aldo-keto reductase family 1, member B8 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A multifunctional mouse model to study the role of Samd3. Peters AE, et al. Eur J Immunol, 2022 Feb. PMID 34626120
    2. Smad2 and Smad3 Inversely Regulate TGF-β Autoinduction in Clostridium butyricum-Activated Dendritic Cells. Kashiwagi I, et al. Immunity, 2015 Jul 21. PMID 26141582
    3. Tissue-Specific Actions of Pax6 on Proliferation and Differentiation Balance in Developing Forebrain Are Foxg1 Dependent. Quintana-Urzainqui I, et al. iScience, 2018 Dec 21. PMID 30529950, Free PMC Article
    4. Single-cell transcriptomics of the early developing mouse cerebral cortex disentangle the spatial and temporal components of neuronal fate acquisition. Moreau MX, et al. Development, 2021 Jul 15. PMID 34170322
    5. Regulatory pathway analysis by high-throughput in situ hybridization. Visel A, et al. PLoS Genet, 2007 Oct. PMID 17953485, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A multifunctional mouse model to study the role of Samd3.
      Title: A multifunctional mouse model to study the role of Samd3.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    sterile alpha motif domain-containing protein 3
    Names
    SAM domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013766.3 → NP_001013788.2  sterile alpha motif domain-containing protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC091763
      Consensus CDS
      CCDS48524.1
      UniProtKB/TrEMBL
      B9EKF8
      Related
      ENSMUSP00000129054.2, ENSMUST00000164660.8
      Conserved Domains (2) summary
      cd09526
      Location:1 → 66
      SAM_Samd3; SAM domain of Samd3 subfamily
      smart00454
      Location:1 → 65
      SAM; Sterile alpha motif

    2. NM_001115154.2 → NP_001108626.1  sterile alpha motif domain-containing protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC091763
      Consensus CDS
      CCDS48525.1
      UniProtKB/Swiss-Prot
      E9QPH5, Q8C4H2
      UniProtKB/TrEMBL
      E9Q3G4
      Related
      ENSMUSP00000057805.6, ENSMUST00000060716.6
      Conserved Domains (2) summary
      cd09526
      Location:1 → 66
      SAM_Samd3; SAM domain of Samd3 subfamily
      smart00454
      Location:1 → 65
      SAM; Sterile alpha motif

    3. NM_001408265.1 → NP_001395194.1  sterile alpha motif domain-containing protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC091763

    4. NM_001408266.1 → NP_001395195.1  sterile alpha motif domain-containing protein 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC091763

    5. NM_001408267.1 → NP_001395196.1  sterile alpha motif domain-containing protein 3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC091763

    6. NM_001408268.1 → NP_001395197.1  sterile alpha motif domain-containing protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC091763
      UniProtKB/TrEMBL
      B9EKF8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      26105465..26148814
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512743.4 → XP_006512806.1  sterile alpha motif domain-containing protein 3 isoform X2

      UniProtKB/Swiss-Prot
      E9QPH5, Q8C4H2
      Conserved Domains (1) summary
      cd09526
      Location:28 → 93
      SAM_Samd3; SAM domain of Samd3 subfamily

    2. XM_006512742.4 → XP_006512805.1  sterile alpha motif domain-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      E9QPH5, Q8C4H2
      Conserved Domains (1) summary
      cd09526
      Location:14 → 79
      SAM_Samd3; SAM domain of Samd3 subfamily

    3. XM_006512744.3 → XP_006512807.1  sterile alpha motif domain-containing protein 3 isoform X3

      See identical proteins and their annotated locations for XP_006512807.1

      UniProtKB/Swiss-Prot
      E9QPH5, Q8C4H2
      Conserved Domains (1) summary
      cl15755
      Location:1 → 25
      SAM_superfamily; SAM (Sterile alpha motif )

    4. XM_011243173.3 → XP_011241475.1  sterile alpha motif domain-containing protein 3 isoform X3

      See identical proteins and their annotated locations for XP_011241475.1

      UniProtKB/Swiss-Prot
      E9QPH5, Q8C4H2
      Conserved Domains (1) summary
      cl15755
      Location:1 → 25
      SAM_superfamily; SAM (Sterile alpha motif )
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C4H2.3 GenPept UniProtKB/Swiss-Prot:Q8C4H2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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