Prss57 serine protease 57 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prss57provided by MGI
Official Full Name: serine protease 57provided by MGI
Primary source: MGI:MGI:1920356
See related: Ensembl:ENSMUSG00000020323 AllianceGenome:MGI:1920356
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NSP4; Prssl1; UNQ782; GLGL782; 2900092M14Rik
Summary: Predicted to enable heparin binding activity and serine-type endopeptidase activity. Predicted to be involved in protein maturation and proteolysis. Predicted to be located in azurophil granule lumen. Predicted to be active in extracellular space. Orthologous to human PRSS57 (serine protease 57). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in placenta adult (RPKM 24.9), lung adult (RPKM 6.4) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (79617308..79630523, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (79781474..79794684, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage.
Title: Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493171

RH139332 (e-PCR)
- UniSTS:221418

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in azurophil granule lumen	ISO Inferred from Sequence Orthology more info
located_in azurophil granule lumen	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine protease 57

Names: neutrophil serine protease 4; protease, serine 57; protease, serine-like 1; serine protease 1-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042710.1 → NP_001036175.1 serine protease 57 precursor

See identical proteins and their annotated locations for NP_001036175.1

Status: VALIDATED

Source sequence(s)

AC151828, AK158376

Consensus CDS

CCDS35968.1

UniProtKB/Swiss-Prot

Q14B24

Related

ENSMUSP00000020573.7, ENSMUST00000020573.13

Conserved Domains (1) summary

cd00190
Location:40 → 264

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

79617308..79630523 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514199.5 → XP_006514262.1 serine protease 57 isoform X1

See identical proteins and their annotated locations for XP_006514262.1

UniProtKB/Swiss-Prot

Q14B24

Conserved Domains (1) summary

cd00190
Location:40 → 264

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_036156043.1 → XP_036011936.1 serine protease 57 isoform X1

UniProtKB/Swiss-Prot

Q14B24

Conserved Domains (1) summary

cd00190
Location:40 → 264

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_011243584.4 → XP_011241886.1 serine protease 57 isoform X1

See identical proteins and their annotated locations for XP_011241886.1

UniProtKB/Swiss-Prot

Q14B24

Conserved Domains (1) summary

cd00190
Location:40 → 264

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_006514201.5 → XP_006514264.1 serine protease 57 isoform X3

Conserved Domains (1) summary

cd00190
Location:40 → 220

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_006514200.5 → XP_006514263.1 serine protease 57 isoform X2

Conserved Domains (1) summary

cd00190
Location:40 → 228

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_006514202.5 → XP_006514265.1 serine protease 57 isoform X4

Conserved Domains (1) summary

cd00190
Location:40 → 185

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...