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    Tph2 tryptophan hydroxylase 2 [ Mus musculus (house mouse) ]

    Gene ID: 216343, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tph2provided by MGI
    Official Full Name
    tryptophan hydroxylase 2provided by MGI
    Primary source
    MGI:MGI:2651811
    See related
    Ensembl:ENSMUSG00000006764 AllianceGenome:MGI:2651811
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ntph
    Summary
    Enables tryptophan 5-monooxygenase activity. Predicted to act upstream of or within serotonin biosynthetic process from tryptophan. Located in neuron projection. Is expressed in several structures, including aorta-gonad-mesonephros; germ cell of ovary; nervous system; retina; and tongue. Used to study melancholic depression. Human ortholog(s) of this gene implicated in autistic disorder; major depressive disorder; and panic disorder. Orthologous to human TPH2 (tryptophan hydroxylase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 1.7), CNS E18 (RPKM 1.0) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Tph2 in Genome Data Viewer
    Location:
    10 D2; 10 63.51 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (114914546..115020927, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (115078641..115185022, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31267 Neighboring gene STARR-seq mESC enhancer starr_27928 Neighboring gene STARR-seq mESC enhancer starr_27929 Neighboring gene predicted gene, 22070 Neighboring gene STARR-seq mESC enhancer starr_27930 Neighboring gene STARR-seq mESC enhancer starr_27931 Neighboring gene TBC1 domain family, member 15 Neighboring gene STARR-seq mESC enhancer starr_27933 Neighboring gene STARR-positive B cell enhancer ABC_E3915 Neighboring gene predicted gene 8942

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC159133

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables iron ion binding  
    enables tryptophan 5-monooxygenase activity  
    enables tryptophan 5-monooxygenase activity PubMed 
    enables tryptophan 5-monooxygenase activity  
    Component Evidence Code Pubs
    is_active_in neuron projection  
    located_in neuron projection PubMed 

    General protein information

    Preferred Names
    tryptophan 5-hydroxylase 2
    Names
    neuronal tryptophan hydroxylase
    tryptophan 5-monooxygenase 2
    NP_775567.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173391.3NP_775567.2  tryptophan 5-hydroxylase 2

      See identical proteins and their annotated locations for NP_775567.2

      Status: VALIDATED

      Source sequence(s)
      AC153825
      Consensus CDS
      CCDS36061.1
      UniProtKB/Swiss-Prot
      Q0VBT4, Q8CGV2
      Related
      ENSMUSP00000006949.9, ENSMUST00000006949.9
      Conserved Domains (3) summary
      TIGR01270
      Location:33483
      Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
      cd04929
      Location:62135
      ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
      pfam00351
      Location:150480
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      114914546..115020927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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