Wnt2b wingless-type MMTV integration site family, member 2B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wnt2bprovided by MGI
Official Full Name: wingless-type MMTV integration site family, member 2Bprovided by MGI
Primary source: MGI:MGI:1261834
See related: Ensembl:ENSMUSG00000027840 AllianceGenome:MGI:1261834
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wnt13
Summary: Predicted to enable cytokine activity and frizzled binding activity. Involved in forebrain regionalization. Acts upstream of or within several processes, including canonical Wnt signaling pathway; mesenchymal-epithelial cell signaling; and regulation of morphogenesis of a branching structure. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; reproductive system; sensory organ; and urethra. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human WNT2B (Wnt family member 2B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in ovary adult (RPKM 10.5), adrenal adult (RPKM 7.2) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.2; 3 45.88 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (104852121..104869025, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (104944805..104961709, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WNT2B Deficiency Causes Enhanced Susceptibility to Colitis Due to Increased Inflammatory Cytokine Production.
Title: WNT2B Deficiency Causes Enhanced Susceptibility to Colitis Due to Increased Inflammatory Cytokine Production.
WNT2B activates macrophages via NF-kappaB signaling pathway in inflammatory bowel disease.
Title: WNT2B activates macrophages via NF-κB signaling pathway in inflammatory bowel disease.
Ectopic Rod Photoreceptor Development in Mice with Genetic Deficiency of WNT2B.
Title: Ectopic Rod Photoreceptor Development in Mice with Genetic Deficiency of WNT2B.
The findings provided new insights into the pathophysiology of liver fibrosis by characterizing Wnt2b as a novel endogenous suppressor of TLR4 signaling, maintaining tissue homeostasis during the early stage of hepatic fibrosis-associated liver diseases.
Title: Wnt2b attenuates HSCs activation and liver fibrosis through negative regulating TLR4 signaling.
The results reveal a key role of Wnt-Lin28-let7 miRNA signaling in regulating proliferation and neurogenic potential of Muller glial cells in the adult mammalian retina.
Title: Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas.
the present study detected abnormal upregulation in the levels of Wnt2b and Wnt7b, and hypothesized that the alterations may be due to the ectopic opening of chromatin structure.
Title: Abnormal epigenetic regulation of the gene expression levels of Wnt2b and Wnt7b: Implications for neural tube defects.
Mice lacking Wnt2b were viable, fertile, and displayed a normal life span, however, the olfactory bulb in adult Wnt2b mutant mice was significantly reduced in length.
Title: Mice lacking Wnt2b are viable and display a postnatal olfactory bulb phenotype.
targeted inactivation of the TSK gene in mice causes expansion of the ciliary body and up-regulation of Wnt2b and Fzd4 expression in the developing peripheral eye
Title: Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wnt2b (e-PCR), detects polymorphism
- UniSTS:465418

Wnt2b (e-PCR), detects polymorphism
- UniSTS:471322

Wnt2b (e-PCR), detects polymorphism
- UniSTS:527136

Wnt2b (e-PCR), detects polymorphism
- UniSTS:466087

Wnt2b (e-PCR), detects polymorphism
- UniSTS:507316

Wnt2b (e-PCR), detects polymorphism
- UniSTS:508411

Wnt2b (e-PCR), detects polymorphism
- UniSTS:508412

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell signaling	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cellular response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in forebrain regionalization	IEP Inferred from Expression Pattern more info	PubMed
involved_in hematopoietic stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in hematopoietic stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung induction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in male gonad development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesenchymal-epithelial cell signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of branching involved in ureteric bud morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein Wnt-2b

Names: wingless related MMTV integration site 2b; wnt-13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.