Serpinb6d serine (or cysteine) peptidase inhibitor, clade B, member 6d [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpinb6dprovided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade B, member 6dprovided by MGI
Primary source: MGI:MGI:2667783
See related: Ensembl:ENSMUSG00000047889 AllianceGenome:MGI:2667783
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SPI3D; Gm11390
Summary: This gene is a member of the large Serpin gene family. Many members of this family act as protease inhibitors, and have a conserved structure including a reactive center loop (RCL) that can act as a bait for protease targets. Unlike some members of this large gene family, the protein encoded by this gene is an intracellular protein, and lacks an N-terminal signal peptide sequence. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 13. [provided by RefSeq, Jul 2014]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 13 A3.3; 13 13.94 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (33845388..33855568)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (33661405..33671585)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Serpinb6d (e-PCR), detects polymorphism
- UniSTS:531235

RH142113 (e-PCR)
- UniSTS:125075

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protease binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
part_of serine protease inhibitor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine (or cysteine) peptidase inhibitor, clade B, member 6d

Names: serine (or cysteine) proteinase inhibitor, clade B, member 6d

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001076790.2 → NP_001070258.1 serine (or cysteine) peptidase inhibitor, clade B, member 6d

See identical proteins and their annotated locations for NP_001070258.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK136270

Consensus CDS

CCDS36631.1

UniProtKB/TrEMBL

Q3UWK8

Related

ENSMUSP00000063025.8, ENSMUST00000059637.8

Conserved Domains (1) summary

cl00137
Location:4 → 375

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
NM_001300892.1 → NP_001287821.1 serine (or cysteine) peptidase inhibitor, clade B, member 6d

See identical proteins and their annotated locations for NP_001287821.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate splice site in the 5' UTR. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK136270, BC147559

Consensus CDS

CCDS36631.1

UniProtKB/TrEMBL

Q3UWK8

Related

ENSMUSP00000152621.2, ENSMUST00000221681.2

Conserved Domains (1) summary

cl00137
Location:4 → 375

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...