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    R3hdml R3H domain containing-like [ Mus musculus (house mouse) ]

    Gene ID: 100043899, updated on 9-Dec-2024

    Summary

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    Official Symbol
    R3hdmlprovided by MGI
    Official Full Name
    R3H domain containing-likeprovided by MGI
    Primary source
    MGI:MGI:3650937
    See related
    Ensembl:ENSMUSG00000078949 AllianceGenome:MGI:3650937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable peptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human R3HDML (R3H domain containing like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 1.6), kidney adult (RPKM 1.1) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See R3hdml in Genome Data Viewer
    Location:
    2 H3; 2 84.31 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163333364..163344532)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163491439..163502621)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ganglioside-induced differentiation-associated protein 1-like 1 Neighboring gene STARR-seq mESC enhancer starr_06310 Neighboring gene RIKEN cDNA 2310001K24 gene Neighboring gene STARR-positive B cell enhancer ABC_E4516 Neighboring gene fat storage-inducing transmembrane protein 2 Neighboring gene hepatic nuclear factor 4 alpha, opposite strand Neighboring gene STARR-seq mESC enhancer starr_06311 Neighboring gene hepatic nuclear factor 4, alpha Neighboring gene predicted gene, 25881 Neighboring gene Crx opposite strand transcript 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. R3hdml regulates satellite cell proliferation and differentiation. Sakamoto K, et al. EMBO Rep, 2019 Nov 5. PMID 31524320, Free PMC Article
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peptidase inhibitor R3HDML
    Names
    cysteine-rich secretory protein R3HDML
    novel SCP-like extracellular protein domain containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099331.2 → NP_001092801.1  peptidase inhibitor R3HDML precursor

      See identical proteins and their annotated locations for NP_001092801.1

      Status: VALIDATED

      Source sequence(s)
      AL591488
      Consensus CDS
      CCDS38316.1
      UniProtKB/Swiss-Prot
      A2A5I3
      Related
      ENSMUSP00000105043.3, ENSMUST00000109416.3
      Conserved Domains (1) summary
      cd18815
      Location:63 → 208
      CAP_R3HDML; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor R3HDML

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      163333364..163344532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498522.5 → XP_006498585.1  peptidase inhibitor R3HDML isoform X1

      See identical proteins and their annotated locations for XP_006498585.1

      UniProtKB/Swiss-Prot
      A2A5I3
      Conserved Domains (1) summary
      cd18815
      Location:63 → 208
      CAP_R3HDML; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor R3HDML

    2. XM_006498524.4 → XP_006498587.1  peptidase inhibitor R3HDML isoform X2

      Conserved Domains (1) summary
      cl00133
      Location:1 → 95
      CAP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A5I3.1 GenPept UniProtKB/Swiss-Prot:A2A5I3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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