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    Maml3 mastermind like transcriptional coactivator 3 [ Mus musculus (house mouse) ]

    Gene ID: 433586, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Maml3provided by MGI
    Official Full Name
    mastermind like transcriptional coactivator 3provided by MGI
    Primary source
    MGI:MGI:2389461
    See related
    Ensembl:ENSMUSG00000061143 AllianceGenome:MGI:2389461
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mam-2; mKIAA1816
    Summary
    Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription of Notch receptor target. Predicted to be located in nuclear speck. Predicted to be active in nucleoplasm. Is expressed in several structures, including forelimb bud; genitourinary system; neural ectoderm; pancreas epithelium; and paraxial mesenchyme. Orthologous to human MAML3 (mastermind like transcriptional coactivator 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 5.1), colon adult (RPKM 3.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Maml3 in Genome Data Viewer
    Location:
    3 C; 3 22.54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (51595032..52012740, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (51687320..52105319, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5031434O11 gene Neighboring gene SET domain containing (lysine methyltransferase) 7 Neighboring gene STARR-seq mESC enhancer starr_07617 Neighboring gene STARR-seq mESC enhancer starr_07618 Neighboring gene STARR-seq mESC enhancer starr_07619 Neighboring gene STARR-seq mESC enhancer starr_07620 Neighboring gene STARR-positive B cell enhancer ABC_E11183 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51440808-51440917 Neighboring gene STARR-seq mESC enhancer starr_07621 Neighboring gene STARR-seq mESC enhancer starr_07622 Neighboring gene STARR-seq mESC enhancer starr_07623 Neighboring gene STARR-seq mESC enhancer starr_07624 Neighboring gene predicted gene, 38247 Neighboring gene microsomal glutathione S-transferase 2 Neighboring gene VISTA enhancer mm1010 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51549117-51549270 Neighboring gene predicted gene, 46803 Neighboring gene VISTA enhancer mm1452 Neighboring gene STARR-seq mESC enhancer starr_07625 Neighboring gene VISTA enhancer mm1388 Neighboring gene STARR-seq mESC enhancer starr_07626 Neighboring gene STARR-positive B cell enhancer ABC_E1019 Neighboring gene STARR-positive B cell enhancer ABC_E7911 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51839623-51839732 Neighboring gene STARR-positive B cell enhancer ABC_E3430 Neighboring gene predicted gene, 30074 Neighboring gene STARR-seq mESC enhancer starr_07632 Neighboring gene olfactory receptor family 14 subfamily M member 1, pseudogene 1 Neighboring gene predicted gene, 30125

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. Wu L, et al. Mol Cell Biol, 2002 Nov. PMID 12370315, Free PMC Article
    2. Identification of oscillatory genes in somitogenesis from functional genomic analysis of a human mesenchymal stem cell model. William DA, et al. Dev Biol, 2007 May 1. PMID 17362910, Free PMC Article
    3. Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo. Oyama T, et al. Development, 2011 Dec. PMID 22069191
    4. The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program. Chalamalasetty RB, et al. Nat Commun, 2011 Jul 12. PMID 21750544, Free PMC Article
    5. The candidate splicing factor Sfswap regulates growth and patterning of inner ear sensory organs. Moayedi Y, et al. PLoS Genet, 2014 Jan. PMID 24391519, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.
      Title: Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1816, MGC59565

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription of Notch receptor target IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mastermind-like protein 3
    Names
    mastermind like 3
    mastermind-2
    mastermind-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004176.3 → NP_001004176.2  mastermind-like protein 3

      See identical proteins and their annotated locations for NP_001004176.2

      Status: VALIDATED

      Source sequence(s)
      AC116729, AC158347
      Consensus CDS
      CCDS17342.2
      UniProtKB/TrEMBL
      D4QGC2
      Related
      ENSMUSP00000112637.2, ENSMUST00000121440.4
      Conserved Domains (1) summary
      pfam09596
      Location:67 → 124
      MamL-1; MamL-1 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      51595032..52012740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501645.5 → XP_006501708.1  mastermind-like protein 3 isoform X1

      Conserved Domains (3) summary
      PRK13042
      Location:336 → 427
      PRK13042; superantigen-like protein SSL4; Reviewed
      pfam09606
      Location:778 → 1038
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam09596
      Location:67 → 124
      MamL-1; MamL-1 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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