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    Ldlrad1 low density lipoprotein receptor class A domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 546840, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ldlrad1provided by MGI
    Official Full Name
    low density lipoprotein receptor class A domain containing 1provided by MGI
    Primary source
    MGI:MGI:3652166
    See related
    Ensembl:ENSMUSG00000070877 AllianceGenome:MGI:3652166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Is expressed in ductus deferens; prostate gland; and testis. Orthologous to human LDLRAD1 (low density lipoprotein receptor class A domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 7.9) and ovary adult (RPKM 5.5) See more
    Orthologs
    human all
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    Genomic context

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    See Ldlrad1 in Genome Data Viewer
    Location:
    4 C7; 4 50.16 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (107066264..107081341)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (107209078..107221092)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12802 Neighboring gene transcription elongation factor A (SII) N-terminal and central domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E4641 Neighboring gene transmembrane protein 59 Neighboring gene leucine rich repeat containing 42 Neighboring gene STARR-positive B cell enhancer ABC_E4642 Neighboring gene intraflagellar transport 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    low-density lipoprotein receptor class A domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081272.2 → NP_001074741.1  low-density lipoprotein receptor class A domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      AL645723
      Consensus CDS
      CCDS38830.1
      UniProtKB/TrEMBL
      D3YYZ1
      Related
      ENSMUSP00000092521.5, ENSMUST00000094916.5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      107066264..107081341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503244.3 → XP_006503307.1  low-density lipoprotein receptor class A domain-containing protein 1 isoform X4

    2. XM_006503243.5 → XP_006503306.1  low-density lipoprotein receptor class A domain-containing protein 1 isoform X3

    3. XM_011240578.4 → XP_011238880.1  low-density lipoprotein receptor class A domain-containing protein 1 isoform X5

      See identical proteins and their annotated locations for XP_011238880.1

    4. XM_006503242.5 → XP_006503305.1  low-density lipoprotein receptor class A domain-containing protein 1 isoform X2

    5. XM_006503241.5 → XP_006503304.1  low-density lipoprotein receptor class A domain-containing protein 1 isoform X1

    6. XM_006503246.5 → XP_006503309.1  low-density lipoprotein receptor class A domain-containing protein 1 isoform X6

      Conserved Domains (1) summary
      cd00112
      Location:86 → 114
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    7. XM_011240579.4 → XP_011238881.1  low-density lipoprotein receptor class A domain-containing protein 1 isoform X5

      See identical proteins and their annotated locations for XP_011238881.1

    Nucleotide Protein
    Heading Accession and Version

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