Fdcsp follicular dendritic cell secreted protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fdcspprovided by MGI
Official Full Name: follicular dendritic cell secreted proteinprovided by MGI
Primary source: MGI:MGI:3512757
See related: Ensembl:ENSMUSG00000105888 AllianceGenome:MGI:3512757
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FDC-SP
Summary: Involved in positive regulation of B cell chemotaxis. Acts upstream of with a positive effect on isotype switching to IgD isotypes. Acts upstream of or within with a negative effect on isotype switching to IgE isotypes and isotype switching to IgG isotypes. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 5 E1; 5

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (88056638..88062030)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (87908779..87914171)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results demonstrate a novel biological activity of FDC-SP in controlling B-cell IgA production and identify FDC-SP-deficient mice as a novel mouse model of IgAN.
Title: Follicular dendritic cell secreted protein FDC-SP controls IgA production.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_positive_effect isotype switching to IgD isotypes	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_negative_effect isotype switching to IgE isotypes	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_negative_effect isotype switching to IgG isotypes	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of B cell chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed

General protein information

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Preferred Names: follicular dendritic cell secreted peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.