Cmtm4 CKLF-like MARVEL transmembrane domain containing 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cmtm4provided by MGI
Official Full Name: CKLF-like MARVEL transmembrane domain containing 4provided by MGI
Primary source: MGI:MGI:2142888
See related: Ensembl:ENSMUSG00000096188 AllianceGenome:MGI:2142888
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm9853; Cklfsf4
Summary: Predicted to be active in membrane. Is expressed in gut; nose; submandibular gland primordium; and urinary system. Orthologous to human CMTM4 (CKLF like MARVEL transmembrane domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in colon adult (RPKM 23.3), kidney adult (RPKM 13.2) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.04 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (105074823..105122439, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (104348191..104395807, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cmtm4 deficiency exacerbates colitis by inducing gut dysbiosis and S100a8/9 expression.
Title: Cmtm4 deficiency exacerbates colitis by inducing gut dysbiosis and S100a8/9 expression.
CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology.
Title: CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology.
These findings elucidate the roles of CMTM4 in male fertility.
Title: Integrated Analyses of Phenotype and Quantitative Proteome of CMTM4 Deficient Mice Reveal Its Association with Male Fertility.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Gene trapped (1)
Targeted (3) 1 citation

General gene information

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Markers

D19397 (e-PCR)
- UniSTS:179800

UniSTS:224441 (e-PCR)
- UniSTS:224441

AW049954 (e-PCR)
- UniSTS:208318

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CKLF-like MARVEL transmembrane domain-containing protein 4

Names: chemokine-like factor super family 4; chemokine-like factor superfamily member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.