Tbcb tubulin folding cofactor B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tbcbprovided by MGI
Official Full Name: tubulin folding cofactor Bprovided by MGI
Primary source: MGI:MGI:1913661
See related: Ensembl:ENSMUSG00000006095 AllianceGenome:MGI:1913661
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CG22; CKAPI; Ckap1; 2410007D12Rik
Summary: Predicted to enable microtubule plus-end binding activity. Predicted to be involved in cytoplasmic microtubule organization. Predicted to be located in cytosol. Predicted to be active in cell cortex; microtubule plus-end; and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human TBCB (tubulin folding cofactor B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 59.9), CNS E14 (RPKM 49.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 17.33 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (29923554..29931622, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30224129..30232197, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of TBCB leads to the decreased localization of p150 to the microtubule network that might result in a functional modulation of this protein complex.
Title: Tubulin-binding cofactor B is a direct interaction partner of the dynactin subunit p150(Glued).
We show that TBCB overexpression depolymerizes microtubules. We found that this function is based on the ability of TBCB to form a binary complex with TBCE that greatly enhances the efficiency of this cofactor to dissociate tubulin in vivo and in vitro.
Title: Role of cofactors B (TBCB) and E (TBCE) in tubulin heterodimer dissociation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139378 (e-PCR)
- UniSTS:221464

AU041393 (e-PCR)
- UniSTS:159620

D1Bda12 (e-PCR)
- UniSTS:239759

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-tubulin binding	IEA Inferred from Electronic Annotation more info
enables microtubule plus-end binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in post-chaperonin tubulin folding pathway	IEA Inferred from Electronic Annotation more info
involved_in tubulin complex assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in microtubule plus-end	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tubulin-folding cofactor B

Names: cytoskeleton-associated protein 1; cytoskeleton-associated protein CKAPI; tubulin-specific chaperone B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360648.1 → NP_001347577.1 tubulin-folding cofactor B isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC149067

Conserved Domains (2) summary

pfam01302
Location:110 → 178

CAP_GLY; CAP-Gly domain

cl00155
Location:1 → 41

UBQ; Ubiquitin-like proteins
NM_001360649.1 → NP_001347578.1 tubulin-folding cofactor B isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AA718358, AC149067

Conserved Domains (1) summary

cd01789
Location:10 → 92

Alp11_N; Ubiquitin-like domain of Alp11 tubulin-folding cofactor B
NM_025548.4 → NP_079824.2 tubulin-folding cofactor B isoform 1

See identical proteins and their annotated locations for NP_079824.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC149067

Consensus CDS

CCDS21083.1

UniProtKB/Swiss-Prot

Q9CWR6, Q9D1E6, Q9DCZ6

Related

ENSMUSP00000006254.6, ENSMUST00000006254.6

Conserved Domains (2) summary

cd01789
Location:10 → 92

Alp11_N; Ubiquitin-like domain of Alp11 tubulin-folding cofactor B

pfam01302
Location:162 → 229

CAP_GLY; CAP-Gly domain