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    ITPKB inositol-trisphosphate 3-kinase B [ Homo sapiens (human) ]

    Gene ID: 3707, updated on 9-Dec-2024

    Summary

    Official Symbol
    ITPKBprovided by HGNC
    Official Full Name
    inositol-trisphosphate 3-kinase Bprovided by HGNC
    Primary source
    HGNC:HGNC:6179
    See related
    Ensembl:ENSG00000143772 MIM:147522; AllianceGenome:HGNC:6179
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IP3K; IP3KB; PIG37; IP3K-B; IP3-3KB
    Summary
    The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 10.0), fat (RPKM 9.3) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ITPKB in Genome Data Viewer
    Location:
    1q42.12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (226631690..226739282, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (225819873..225927469, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (226819391..226926983, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373116 Neighboring gene Sharpr-MPRA regulatory region 7345 Neighboring gene Sharpr-MPRA regulatory region 13952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:226755704-226756204 Neighboring gene stum, mechanosensory transduction mediator homolog Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:226784052-226784579 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:226785107-226785634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:226789667-226790203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:226790204-226790739 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:226791949-226792628 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:226792629-226793308 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2653 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2654 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:226822865-226823648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:226830147-226830814 Neighboring gene Sharpr-MPRA regulatory region 1086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2657 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:226832149-226832814 Neighboring gene MPRA-validated peak735 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:226834481-226835372 Neighboring gene Sharpr-MPRA regulatory region 9391 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2659 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:226841474-226842065 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:226846645-226847475 Neighboring gene uncharacterized LOC124904529 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:226850479-226851004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2661 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2662 Neighboring gene ITPKB intronic transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2663 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2664 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2665 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:226872731-226873232 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1887 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:226876299-226876798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1888 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1889 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:226896320-226896495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2667 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2669 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:226905393-226905892 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:226911101-226911856 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:226925617-226926116 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:226942001-226942500 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2671 Neighboring gene ribosomal protein S27 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2672 Neighboring gene uncharacterized LOC124904530 Neighboring gene Sharpr-MPRA regulatory region 12356

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol hexakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables inositol-1,4,5-trisphosphate 3-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in common myeloid progenitor cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inositol trisphosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in myeloid cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of myeloid cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neutrophil apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of alpha-beta T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive thymic T cell selection IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    inositol-trisphosphate 3-kinase B
    Names
    IP3 3-kinase B
    IP3K B
    inositol 1,4,5-trisphosphate 3-kinase B
    insP 3-kinase B
    proliferation-inducing protein 37
    NP_001375333.1
    NP_002212.3
    XP_016856700.1
    XP_054192400.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001388404.1NP_001375333.1  inositol-trisphosphate 3-kinase B isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL365444
      Consensus CDS
      CCDS91167.1
      Related
      ENSP00000355748.1, ENST00000366784.1
    2. NM_002221.4NP_002212.3  inositol-trisphosphate 3-kinase B isoform 1

      See identical proteins and their annotated locations for NP_002212.3

      Status: REVIEWED

      Source sequence(s)
      AJ242780, AK313801, AL365444, BC015009, Y18024
      Consensus CDS
      CCDS1555.1
      UniProtKB/Swiss-Prot
      P27987, Q5VWL9, Q5VWM0, Q96BZ2, Q96JS1, Q9UH47
      Related
      ENSP00000411152.1, ENST00000429204.6
      Conserved Domains (2) summary
      PHA03247
      Location:33369
      PHA03247; large tegument protein UL36; Provisional
      pfam03770
      Location:726937
      IPK; Inositol polyphosphate kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      226631690..226739282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001211.3XP_016856700.1  inositol-trisphosphate 3-kinase B isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      225819873..225927469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336425.1XP_054192400.1  inositol-trisphosphate 3-kinase B isoform X1