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    ACY3 aminoacylase 3 [ Homo sapiens (human) ]

    Gene ID: 91703, updated on 27-Nov-2024

    Summary

    Official Symbol
    ACY3provided by HGNC
    Official Full Name
    aminoacylase 3provided by HGNC
    Primary source
    HGNC:HGNC:24104
    See related
    Ensembl:ENSG00000132744 MIM:614413; AllianceGenome:HGNC:24104
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACY-3; ASPA2; HCBP1
    Summary
    Predicted to enable aminoacylase activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney (RPKM 28.0), duodenum (RPKM 26.6) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ACY3 in Genome Data Viewer
    Location:
    11q13.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (67642555..67650730, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (67637243..67645420, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67410026..67418201, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 370 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3647 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67399437-67399966 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67400495-67401024 Neighboring gene nudix hydrolase 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67401025-67401552 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67401848-67402406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67402407-67402965 Neighboring gene T-box transcription factor 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67411697-67412266 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67412267-67412834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67416073-67416595 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5124 Neighboring gene aldehyde dehydrogenase 3 family member B2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5125 Neighboring gene ribosomal protein L37 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC9740

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aminoacylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables aminoacylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 

    General protein information

    Preferred Names
    N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
    Names
    HCV core-binding protein 1
    acylase III
    aspartoacylase (aminoacylase) 3
    aspartoacylase (aminocyclase) 3
    aspartoacylase-2
    hepatitis C virus core-binding protein 1
    NP_542389.1
    XP_016874038.1
    XP_016874039.1
    XP_016874040.1
    XP_047283824.1
    XP_054226471.1
    XP_054226472.1
    XP_054226473.1
    XP_054226474.1
    XP_054226475.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080658.2NP_542389.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)

      See identical proteins and their annotated locations for NP_542389.1

      Status: VALIDATED

      Source sequence(s)
      AP003385, BC008689
      Consensus CDS
      CCDS8175.1
      UniProtKB/Swiss-Prot
      Q96HD9
      Related
      ENSP00000255082.3, ENST00000255082.8
      Conserved Domains (1) summary
      cd06909
      Location:12300
      M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      67642555..67650730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427868.1XP_047283824.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X3

      UniProtKB/TrEMBL
      E9PRA7
      Related
      ENSP00000434270.1, ENST00000529256.1
    2. XM_017018551.2XP_016874040.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X2

    3. XM_017018549.2XP_016874038.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X1

    4. XM_017018550.2XP_016874039.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      67637243..67645420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370500.1XP_054226475.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X3

      UniProtKB/TrEMBL
      E9PRA7
    2. XM_054370499.1XP_054226474.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X4

    3. XM_054370498.1XP_054226473.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X2

    4. XM_054370496.1XP_054226471.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X1

    5. XM_054370497.1XP_054226472.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X1