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    SLC38A4 solute carrier family 38 member 4 [ Homo sapiens (human) ]

    Gene ID: 55089, updated on 9-Dec-2024

    Summary

    Official Symbol
    SLC38A4provided by HGNC
    Official Full Name
    solute carrier family 38 member 4provided by HGNC
    Primary source
    HGNC:HGNC:14679
    See related
    Ensembl:ENSG00000139209 MIM:608065; AllianceGenome:HGNC:14679
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATA3; NAT3; PAAT; SNAT4
    Summary
    SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids. The transport of cationic amino acids by SLC38A4 is Na(+) and pH independent, while the transport of neutral amino acids is Na(+) and pH dependent (Hatanaka et al., 2001 [PubMed 11342143]).[supplied by OMIM, Mar 2008]
    Expression
    Restricted expression toward liver (RPKM 138.1) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC38A4 in Genome Data Viewer
    Location:
    12q13.11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (46764761..46832431, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (46724005..46791701, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (47158544..47219780, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene SLC38A4 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:46997992-46998511 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:47011695-47012195 Neighboring gene olfactory receptor family 7 subfamily A member 19 pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:47063431-47064104 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:47064118-47064618 Neighboring gene microtubule affinity regulating kinase 3 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:47219240-47219798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:47219799-47220356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:47225315-47226123 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:47232393-47232579 Neighboring gene uncharacterized LOC124902924 Neighboring gene uncharacterized LOC124902925

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10191, MGC126876

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in L-alanine import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in L-arginine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in amino acid transport TAS
    Traceable Author Statement
    more info
     
    involved_in neutral amino acid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in microvillus membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    sodium-coupled neutral amino acid transporter 4
    Names
    N amino acid transporter 3
    Na(+)-coupled neutral amino acid transporter 4
    amino acid transporter A3
    amino acid transporter system A3
    system A amino acid transporter 3
    system N amino acid transporter 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143824.2NP_001137296.1  sodium-coupled neutral amino acid transporter 4

      See identical proteins and their annotated locations for NP_001137296.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC008014, AC080136, KF459548
      Consensus CDS
      CCDS8750.1
      UniProtKB/Swiss-Prot
      A8K553, Q969I6
      Related
      ENSP00000389843.1, ENST00000447411.5
      Conserved Domains (2) summary
      COG0814
      Location:71534
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:73535
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. NM_018018.5NP_060488.2  sodium-coupled neutral amino acid transporter 4

      See identical proteins and their annotated locations for NP_060488.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC008014, AC080136, KF459548
      Consensus CDS
      CCDS8750.1
      UniProtKB/Swiss-Prot
      A8K553, Q969I6
      Related
      ENSP00000266579.4, ENST00000266579.9
      Conserved Domains (2) summary
      COG0814
      Location:71534
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:73535
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      46764761..46832431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005268997.3XP_005269054.1  sodium-coupled neutral amino acid transporter 4 isoform X1

      See identical proteins and their annotated locations for XP_005269054.1

      UniProtKB/Swiss-Prot
      A8K553, Q969I6
      Conserved Domains (2) summary
      COG0814
      Location:71534
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:73535
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      46724005..46791701 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372383.1XP_054228358.1  sodium-coupled neutral amino acid transporter 4 isoform X1

      UniProtKB/Swiss-Prot
      A8K553, Q969I6
    2. XM_054372385.1XP_054228360.1  sodium-coupled neutral amino acid transporter 4 isoform X1

      UniProtKB/Swiss-Prot
      A8K553, Q969I6
    3. XM_054372384.1XP_054228359.1  sodium-coupled neutral amino acid transporter 4 isoform X1

      UniProtKB/Swiss-Prot
      A8K553, Q969I6