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    BMT2 25S rRNA (adenine2142-N1)-methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852438, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BMT2
    Official Full Name
    25S rRNA (adenine2142-N1)-methyltransferase
    Primary source
    SGD:S000000345
    Locus tag
    YBR141C
    See related
    AllianceGenome:SGD:S000000345; FungiDB:YBR141C; VEuPathDB:YBR141C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables rRNA (adenine) methyltransferase activity. Predicted to be involved in rRNA methylation. Located in nucleolus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BMT2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (527025..528038, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene carboxypeptidase C Neighboring gene GTPase-activating protein IRA1 Neighboring gene putative ATP-dependent RNA helicase Neighboring gene translation termination factor eRF1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in Saccharomyces cerevisiae. Sharma S, et al. Nucleic Acids Res, 2013 May 1. PMID 23558746, Free PMC Article
    2. High-content screening of yeast mutant libraries by shotgun lipidomics. Tarasov K, et al. Mol Biosyst, 2014 Jun. PMID 24681539
    3. Multiple Motif Scanning to identify methyltransferases from the yeast proteome. Petrossian TC, et al. Mol Cell Proteomics, 2009 Jul. PMID 19351663, Free PMC Article
    4. Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae. Iacovella MG, et al. Nucleic Acids Res, 2018 Sep 6. PMID 30011030, Free PMC Article
    5. Structural and functional analysis of ribosome assembly factor Efg1. Shu S, et al. Nucleic Acids Res, 2018 Feb 28. PMID 29361028, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study reports the identification of a new gene YBR141C [BMT2, (base methyltransferase of 25S RNA)] responsible for m1A2142 base modification of helix 65 in 25S rRNA of S. cerevisiae.
      Title: Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (adenine) methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (adenine) methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (adenine) methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    25S rRNA (adenine2142-N1)-methyltransferase
    NP_009699.2
    • Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of large subunit (LSU) rRNA at position 2142; belongs to Rossmann fold superfamily; null mutant exhibits abnormal lipid metabolic phenotype; not an essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      527025..528038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178489.2 → NP_009699.2  TPA: 25S rRNA (adenine2142-N1)-methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009699.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQD7, P38278
      UniProtKB/TrEMBL
      A6ZL84, G2W9E4, N1P9H6
      Conserved Domains (1) summary
      pfam11968
      Location:125 → 335
      Bmt2; 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38278.2

    Gene LinkOut

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