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    KRT79 keratin 79 [ Homo sapiens (human) ]

    Gene ID: 338785, updated on 9-Dec-2024

    Summary

    Official Symbol
    KRT79provided by HGNC
    Official Full Name
    keratin 79provided by HGNC
    Primary source
    HGNC:HGNC:28930
    See related
    Ensembl:ENSG00000185640 MIM:611160; AllianceGenome:HGNC:28930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K6L; KRT6L
    Summary
    Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in skeletal muscle, skin and scalp. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]
    Expression
    Biased expression in skin (RPKM 6.3), fat (RPKM 0.8) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See KRT79 in Genome Data Viewer
    Location:
    12q13.13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (52821408..52834311, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (52785865..52798767, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53215192..53228095, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:53184490-53185689 Neighboring gene keratin 3 Neighboring gene MPRA-validated peak1735 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53206971-53207472 Neighboring gene keratin 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53212003-53212504 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:53230567-53231766 Neighboring gene keratin 78 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53263818-53264318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53264319-53264819 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4485 Neighboring gene Sharpr-MPRA regulatory region 10657 Neighboring gene ribosomal protein L7 pseudogene 41

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • FLJ26646

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    keratin, type II cytoskeletal 79
    Names
    CK-79
    K79
    cytokeratin-79
    keratin 6L
    keratin 79, type II
    type-II keratin Kb38

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012323.1 RefSeqGene

      Range
      4983..17886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_175834.3NP_787028.1  keratin, type II cytoskeletal 79

      See identical proteins and their annotated locations for NP_787028.1

      Status: REVIEWED

      Source sequence(s)
      AC107016, AJ564105, BC039148
      Consensus CDS
      CCDS8839.1
      UniProtKB/Swiss-Prot
      Q5XKE5, Q6P465, Q7Z793
      Related
      ENSP00000328358.5, ENST00000330553.6
      Conserved Domains (2) summary
      pfam00038
      Location:141456
      Filament; Intermediate filament protein
      pfam16208
      Location:30138
      Keratin_2_head; Keratin type II head

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      52821408..52834311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      52785865..52798767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)