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    NOL7 nucleolar protein 7 [ Homo sapiens (human) ]

    Gene ID: 51406, updated on 9-Dec-2024

    Summary

    Official Symbol
    NOL7provided by HGNC
    Official Full Name
    nucleolar protein 7provided by HGNC
    Primary source
    HGNC:HGNC:21040
    See related
    Ensembl:ENSG00000225921 MIM:611533; AllianceGenome:HGNC:21040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PQBP3; RARG-1; C6orf90; dJ223E5.2
    Summary
    The protein encoded by this gene localizes to the nucleolus, where it maintains nucleolar structure and cell growth rates. The encoded protein also functions as a tumor suppressor and regulator of angiogenesis. The RB tumor suppressor gene recruits transcription factors to this gene and positively regulates its expression. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]
    Expression
    Ubiquitous expression in testis (RPKM 25.5), thyroid (RPKM 22.2) and 25 other tissues See more
    Orthologs
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    Genomic context

    See NOL7 in Genome Data Viewer
    Location:
    6p23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (13615335..13632470)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (13488892..13506009)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (13615567..13632702)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene sirtuin 5 Neighboring gene uncharacterized LOC105374938 Neighboring gene uncharacterized LOC124901263 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24038 Neighboring gene RAN binding protein 9 Neighboring gene U7 small nuclear RNA Neighboring gene Sharpr-MPRA regulatory region 12249 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16935 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16937 Neighboring gene uncharacterized LOC124901264

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC71933

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ribosomal small subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    U3 small nucleolar RNA-associated protein NOL7
    Names
    U3 snoRNA-associated protein NOL7
    nucleolar protein 7, 27kDa
    nucleolar protein of 27 kDa
    polyglutamine binding protein 3
    retinoic acid repressible protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317724.2NP_001304653.1  U3 small nucleolar RNA-associated protein NOL7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AF172066, BU071935
      Consensus CDS
      CCDS4528.1
      UniProtKB/Swiss-Prot
      Q5T297, Q9UMY1, Q9Y3U7
      Conserved Domains (1) summary
      pfam08157
      Location:172234
      NUC129; NUC129 domain
    2. NM_016167.5NP_057251.2  U3 small nucleolar RNA-associated protein NOL7

      See identical proteins and their annotated locations for NP_057251.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AF172066, BM510944, CX760811
      Consensus CDS
      CCDS4528.1
      UniProtKB/Swiss-Prot
      Q5T297, Q9UMY1, Q9Y3U7
      Related
      ENSP00000405674.2, ENST00000451315.7
      Conserved Domains (1) summary
      pfam08157
      Location:172234
      NUC129; NUC129 domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      13615335..13632470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      13488892..13506009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)